Fifty-nine male patients and 41 female patients with uncomplicated gonorrhoea were treated with an intramuscular dose of 1600 mg sulphamethoxazole plus 320 mg trimethoprim followed by an oral dose of 2400 mg sulphamethoxazole plus 480 mg trimethoprim 12 hours later. Forty-nine out of 52 male patients and 37 out of 38 female patients who were re-examined were cured. One of the men probably had a...

Introduction Although co-trimoxazole ('Septrin', 'Bactrim') is in common use, the incidence of associated erythropoietic disturbance is low. This is surprising, since the trimethoprim component has been shown to have some action on human dihydrofolate reductase (Hitchings, 1969) and the sulphamethoxazole might be expected to cause haematological complications as do other sulphonamides (Laurence...

419 patients with uncomplicated gonorrhoea were treated with sulphamethoxazole 4 g. combined with trimethoprim 0-8 g. divided into two doses with an 8-hr interval. The failure rate was 1-9 per cent. Parallel with this trial, 319 patients received pivampicillin 1-4 g. combined with probenecid 1 g,; the failure rate was 0-9 per cent. Side-effects were few, four patients in the first group and one...

Out of 210 isolates of Haemophilus influenzae obtained from the sputum of 63 patients with chronic respiratory infections 109 (52%) were resistant to trimethoprim-sulphamethoxazole by the disc test. The minimal inhibitory concentrations of trimethoprim for 17 out of 18 strains recorded as resistant were 10 mug/ml or higher. Resistant strains were isolated from time to time from 32 (82%) out of ...

Three hundred and eighteen Escherichia coli isolates from stools of healthy volunteers and outpatients from a major university hospital in southern Thailand were tested for the presence of class 1 integrons using multiplex-PCR and for their susceptibility against 12 antimicrobial agents using standard disc diffusion method. Based on the presence of intl1, 162 isolates harbored class 1 integrons...

DARREL, J.H., GARROD, L.P. & WATERWORTH, P.M. (1968) Trimethoprim: laboratory and clinical studies. Journal of Clinical Pathology, 21, 202. DAWSON, D.W. & ROUTLEDGE, R.C. (1971) Trimethoprim and sulphamethoxazole. British Medical Journal, 4, 364. EVANS, D.I.K. & TELL, R. (1969) Agranulocytosis after trimethoprim and sulphamethoxazole. British Medical Journal, 1, 578. HAMMETT, J.F. (1970) Thromb...

A simple and rapid indirect potentiometric titration of sulphamethoxazole in the presence of trimethoprim contained in co-trimazole tablets is described. The method is based on the formation of a complex of sulphamethoxazole with a known excess of silver ions and the titration of unreacted silver ion potentiometrically using an inexpensive lab-made copper based mercury film electrode (CBMFE). T...