In our previous paper (Karamchandani and Haider, 1945), certain measures were outlined to combat cerebro-spinal fever in this station. These proved to be effective and were applied in the central command. Only 10 cases occurred during the first seven months of 1945, but in all 13 cases were treated with sulphamezathine which was administered as follows :? Six grammes in 20 c.cm. were given by t...

558.35 Aklomide. 558.55 Amprolium. 558.58 Amprolium and ethopabate. 558.59 Apramycin. 558.60 Arsanilate sodium. 558.62 Arsanilic acid. 558.76 Bacitracin methylene disalicylate. 558.78 Bacitracin zinc. 558.95 Bambermycins. 558.105 [Reserved] 558.115 Carbadox. 558.120 Carbarsone (not U.S.P.). 558.128 Chlortetracycline. 558.140 Chlortetracycline and sulfamethazine. 558.145 Chlortetracycline, proca...

In-house validation of a liquid chromatographic method for determination of sulfamethazine in swine and cattle feed was performed to verify that the method was ready for collaborative study under AOAC INTERNATIONAL guidelines. In this method, sulfamerazine is added during the extraction procedure and is used as an internal standard to correct for variable recovery of sulfamethazine from a varie...

Pharmaceuticals have been detected in the soil environment where there is the potential for uptake into crops. This study explored the fate and uptake of pharmaceuticals (carbamazepine, diclofenac, fluoxetine, propranolol, sulfamethazine) and a personal care product (triclosan) in soil-plant systems using radish (Raphanus sativus) and ryegrass (Lolium perenne). Five of the six chemicals were de...

Adsorption of three sulfonamide antimicrobials to clay minerals was investigated as a function of pH, ionic strength, and type of exchangeable cation. Sulfonamide antimicrobial adsorption exhibited pronounced pH dependence consistent with sorbate speciation and clay properties. Sulfonamide antimicrobials did not intercalate into montmorillonite, and surface charge density influenced sorption by...

It has been pointed out (Rao et al, 1970) that with the advent of intermittent treatment regimens the determination of the acetylator phenotype has become of practical importance. It has recently been shown that rapid acetylators have an inferior response to slow acetylators when their tuberculosis is treated with once weekly treatment regimens (Menon, 1968; Tuberculosis Chemotherapy Centre, Ma...

In the asymmetric unit of the title co-crystal, C(12)H(14)N(4)O(2)S·C(7)H(5)NO(4), the sulfamethazine and 2-nitro-benzoic acid mol-ecules form a heterodimer through inter-molecular amide-carb-oxy-lic acid N-H⋯O and carb-oxy-lic acid-pyrimidine O-H⋯N hydrogen-bond pairs, giving a cyclic motif [graph set R(2) (2)(8)]. The dihedral angle between the two aromatic ring systems in the sulfamethazine ...

In the present study, we have measured acetylation phenotype in 45 patients who had undergone surgical resection of a primary adenocarcinoma of the breast and in 48 patients or volunteer subjects with no breast disease. Phenotype was determined by measuring the ratio of N-acetylsulfamethazine to N-acetylsulfamethazine plus sulfamethazine in plasma 6 h after a p.o. dose of sulfamethazine. In the...