The pharmacokinetics of 2,000 mg of sulfadiazine administered twice daily (BID) versus those of 1,000 mg administered four times a day were compared in eight human immunodeficiency virus-infected patients. No differences in pharmacokinetic parameters were detected between the regimens. These data provide a pharmacokinetic rationale for BID dosing of sulfadiazine for the treatment and suppressio...

Antibiotics, such as sulfadiazine, reach agricultural soils directly through manure of grazing livestock or indirectly through the spreading of manure or sewage sludge on the field. Knowledge about the fate of antibiotics in soils is crucial for assessing the environmental risk of these compounds, including possible transport to the groundwater. Transport of (14)C-labelled sulfadiazine was inve...

Sulphonamide motif is found extensively in numerous chemotherapeutic drug candidates, it acts by stopping the production of folate inside bacterial cell. Current research has established synthesis and characterization new bioprecursor prodrugs sulfadiazine. The first prodrug, 3, was synthesized via coupling diazonium salt sulfadiazine with ethyl acetoacetate AcONa at 0 °C. second sulfadiazine-p...

Silver sulfadiazine has been used as topical medication in the treatment of partial-thickness burns or secondary degree burns for many years. Pain during daily wound cleansing is the main problem. Urgotul SSD, a hydrocolloid dressing with silver sulfadiazine (SSD) has been reported to reduce infection and exhibit antimicrobial activity in burn wounds. The purpose of the present study was to com...

The title compound, [Mn(C(10)H(9)N(4)O(2)S)(2)(C(10)H(8)N(2))], contains a distorted octa-hedral [Mn(sdz)(2)(bpy)] (sdz is the sulfadiazine anion and bpy is 2,2'-bipyridine) complex mol-ecule. A three-dimensional network is generated by N-H⋯N, N-H⋯O and C-H⋯O hydrogen bonds from the sulfadiazine ligands.

A pharmacokinetic and bioavailability study of sulfadiazine combined with trimethoprim (sulfadiazine/trimethoprim) was carried out in fifteen healthy young ostriches after intravenous (i.v.), intramuscular (i.m.) and oral administration at a total dose of 30 mg/kg body weight (bw) (25 and 5 mg/kg bw of sulfadiazine and trimethoprim, respectively). The study followed a single dose, three periods...

Objective: To evaluate the efficacy of dressing based on silver as nanocrystalline silver and silver sulfadiazine in patients with burns and clinical signs of infection, in the healing process, seeking a favorable outcome of local therapy. Methods: A prospective and exploratory study, carried out with patients with burns with a quantitative approach by the method of clinical investigation. The ...

Introduction: Celosia argentea (Amaranthaceae; CA), is applied for the management of several conditions including, wounds, haemorrhagic conditions, and gynaecological diseases. Alcoholic and ethyl acetate extracts of the CA leaves, as an ointment formulation (10% w/w), were assessed for the healing efficacy on rat burn wound models and was compared with silver sulfadiazine and in vitro cytoxici...

background wound healing is widely discussed in the medical literature. this study compared the healing effect of aloe vera extract and silver sulfadiazine in burn injuries in experimental rat model. methods sixteen rats were randomly assigned to one of two groups, each group 8 rats. a deep second-degree burn on the lower back and 3rd degree burn on upper back of each rat were created with a st...