THE treatment of trachoma with aureomycin is still far from satisfactory, in spite of favourable reports from such authorities as Braley and Sanders (1949), Boase (1950), Duke-Elder, Ainslie, and Boase (1950), and Tanaka (1951). The drug had been given a fair trial here, but the results have been uncertain in pannus as well as in the lid condition. Similarly disappointing results were reported ...

Mutations in Plasmodium falciparum dihydropteroate synthase have been linked to resistance to the antimalarial drug, sulfadoxine, which competes with the dihydropteroate synthase substrate, p-aminobenzoate. In an effort to evaluate the role of these mutations in a simple model system, we have expressed six relevant alleles of the P. falciparum dihydropteroate synthase gene in Escherichia coli. ...

Different iron-based cathode catalysts have been studied for oxygen reduction reaction (ORR) in neutral media and then applied into microbial fuel cells (MFC). The catalysts have been synthesized using sacrificial support method (SSM) using eight different organic precursors named Niclosamide, Ricobendazole, Guanosine, Succinylsulfathiazole, Sulfacetamide, Quinine, Sulfadiazine and Pyrazinamide...

Leonard B. Weinstock, MD Washington University School of Medicine, St Louis, MO; Specialists in Gastroenterology, LLC, St Louis, MO Rosacea is a skin disease that manifests as flushing, persistent skin redness (ie, erythematous form), small rounded bumps on the skin (ie, papulopustular form), or dilated superficial blood vessels (ie, telangiectasia). The pathophysiology of rosacea is unknown, b...

Introduction: Molecular hybridization is a synthesis strategy in which new molecules are obtained by linking two drugs or pharmacophoric groups. Skin conditions treatment, such as acne, generally  requires the association of drugs, for instance, sulfacetamide and salicylic acid. The present study aimed to synthesize characterize drug candidate molecular using We also intended further explore ev...

Verticillium dahliae is a phytopathogenic fungus that causes vascular wilt disease in a wide variety of crop plants, thereby causing extensive economic loss. In present study, one V. dahliae T-DNA mutant M01C06 showed the pathogenicity loss on cotton, and the expression of a flanking gene encoding cytochrome P450 monooxygenase (P450, VdCYP1) was strongly repressed. P450s of fungi could affect t...

Drought causes an increase in some gene expression in plant tissues such as plasma membrane intrinsic proteins type 1 (PIP1), 9-cis-epoxycarotenoid dioxygenase (NCED) SlAREB1. The effects of exogenous abscisic acid (ABA) and two sulfonamide compounds, namely, sulfacetamide (Sa) and sulfasalazine (SS) were studied on gene expression of tomato (Lycopersicon esculentum Mill. Cv. Super chief) under...