Aurones are minor flavonoids that possess a wide variety of bioactivity, including antioxidant, anticancer, and enzyme inhibitory activity. L-proline-based natural deep eutectic solvents (NaDES) were synthesized applied as catalysts for the Knoevenagel condensation reaction between benzofuranone substituted benzaldehydes to produce aurones in high yields purity. The vanillin served model reacti...

Synthesis of 3-methoxy acetophenone with substituted benzaldehydes resulted in a number novel chalcones. The chalcones were then treated to cyclization reaction hydroxylamine hydrochloride ethanol enable the synthesis isoxazole derivatives. After purification, structures synthesized compounds identified using TLC, FTIR, 1H NMR, 13C NMR and Mass spectroscopy. carrageenan-induced paw edema method...

A simple, efficient, and general method has been developed for the synthesis of various α-aminophosphonate derivatives 4a-4l by treatment of substituted benzaldehydes and aniline with bis(2-methoxyethyl)or bis(2-ethoxyethyl) phosphite under microwave irradiation without solvents and catalysts. The products were characterized by elemental analysis, IR, H-NMR, Cand P-NMR spectra. The X-ray crysta...

Studies on the stable hemiaminals and Schiff bases formation in the reaction of substituted benzaldehydes with primary 3,5-dimethyl-1,2,4-triazole 4-amine were carried out under neutral conditions. These products were investigated by IR, Raman, MS, ¹H- and (13)C-NMR spectra as well as by X-ray crystallography. The effect of reaction conditions: temperature, polarity of the solvents utilized, su...

In this work, we report a novel method for selective oxidation of benzyl alcohols to benzaldehydes. Neither solvent nor promoters are needed: a polymeric microporous membrane acts as a barrier to “keep in contact” the two phases: the organic phase containing the substrate, benzyl alcohols and the products, benzaldehydes and the aqueous phase with the catalyst and the oxidant, hydrogen peroxide....

A series of 1-(2-chloro-5-nitrophenyl)-3-phenyl-2-propenones were synthesized from 2-chloro-5-nitroacetophenone with various substituted benzaldehydes by crossed-Aldol condensation. The synthesized compounds have been characterized by their physical constants and spectral data. The antimicrobial activities of synthesized 1, 3-diphenyl-2-propenone compounds have been evaluated by Kirby-Baur disc...

The presence of a nonspecific NADPH-linked aldehyde reductase (alcohol: NADP oxidoreductase, EC 1.1.1.2) was observed in various areas of bovine brain in vitro. In the midbrain, hypothalamus, and pons, the rate of NADPH oxidation, with p-nitrobenzaldehyde as substrate, was approximately 4.0 nmoles per min per mg of protein; but somewhat lower values were obtained when other regions of the brain...

The partial purification of the enzyme, aromatic aldehydeketone reductase (aromatic A-K reductase), from rabbit kidney cortex is described. Aromatic A-K reductase utilizes TPNH but not DPNH as a cosubstrate. Substituted benzaldehydes and acetophenones are readily reduced to carbinols. Aromatic A-K reductase does not, however, catalyze the reverse reaction, the dehydrogenation of carbinols under...

An efficient and green method has been developed for the synthesis of new substituted Hantzsch thiazole derivatives in 79%-90% yield, via the one-pot multi-component procedure, by the reaction of 3-(bromoacetyl)-4-hydroxy-6-methyl-2H-pyran-2-one, thiourea and substituted benzaldehydes in the presence of silica supported tungstosilisic acid, as a reusable catalyst, under conventional heating or ...