OBJECTIVE Tuberous sclerosis complex is expressed throughout the body, resulting in a range of clinical manifestations that can be challenging to manage. RESULTS The authors report a patient who presented at age 3.5 years with several suspected seizures and was diagnosed with tuberous sclerosis complex following the discovery of numerous bilateral cortical tubers and subependymal nodules on m...

Unidad Académica de Medicina de la Universidad Autónoma de Nayarit, México; Departamento de Neuropatología. Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, México; Servicio de Neurocirugía, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, México; Servicio de Neuropsiquiatría, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Méxi...

AIM Tuberous sclerosis complex has shown a wide variety of clinical, pathologic and radiologic manifestations. Many tumor types are found in tuberous sclerosis, which includes subependimal giant cell astrositoma. The aim of this study is to focus on surgical timing of the tumor. MATERIAL AND METHODS This study included 37 children with tuberous sclerosis presenting to Erciyes Univercity Medic...

Abstract AIMS 5-ALA (Gliolan©) is a valuable surgical tool used predominantly in high grade tumours, which utilises tissue fluorescence to improve the visualisation of brain-tumour interface. This ensures safe maximal resection, while preserving healthy brain. While Gliolan© use low tumours has previously been reported with variable results, reports its and success context SEGA are extremely ra...

giant cell glioblastoma is an extremely rare variant of glioblastoma (who grade iv) which is characterized by a predominance of bizarre, multinucleated giant cells. these tumors comprise of 0.8% of brain tumors and up to 5% of glioblastomas. in pediatric age group, these tumors are still uncommon with only around 53 published cases since 1952. here, we report a case of a 12-year old female pati...

Since the recent publication of the World Health Organization brain tumour classification guidelines in 2007, a significant expansion in the molecular understanding of glioblastoma multiforme (GBM) and its pathological as well as genomic variants has been evident. The purpose of this review article is to evaluate the histopathological, molecular and clinical features surrounding emerging and cu...

giant cell tumors (gct) are benign tumors with potential for aggressive behavior and capacity to metastasize. although rarely lethal, benign bone tumors may be associated with a substantial disturbance of the local bony architecture that can be particularly troublesome in peri-articular locations. its histogenesis remains unclear. it is characterized by a proliferation of mononuclear stromal ce...