Abstarct: Use of herbal medicines prevails in rural and urban areas of the world; especially for treating ailments which allopathic medicines fail to treat. Present study was undertaken for the pharmacological and toxicological evaluation of Mucuna pruriens, Cinnamomum zeylanicum, and Myristica fragrans, alone and in combination. The acute toxicity was studied on mice and sub chronic toxicity a...

Female hooded-Lister rats received either sub-chronic phencyclidine (PCP) (2 mg/kg, n=20) or vehicle (1 ml/kg, n=20) i.p. twice daily for seven days, followed by a sevenday washout period. Rats were challenged with acute PCP or vehicle and tested for locomotor activity to ensure hyperactivity was observed in the sub-chronic PCP treated rats. Rats were then tested on the elevated plus maze and i...

land use optimization is one of the appropriate methods for soil conservation programs that allow watershed managers and decision makers to choose the best land use practices. with the objective of optimizing land use to minimize soil erosion, the present research was conducted in one of the taleghan sub-basins in iran, namely, orazan sub-basin, with an area of 2,706 ha. to achieve the objectiv...

In humans, chronic stressors have long been recognized as potential causes for cardiac dysregulation. Despite this, the underlying mechanistic links responsible for this association are still poorly understood. The purpose of this study was to determine whether exposure to a paradigm of sub-chronic stress can provoke enduring changes on the heart rate of experimental rats and, if so, to reveal ...

conclusions this infection was observed with a diversity of clinical manifestations. therefore, diagnostic difficulty because of the various clinical presentations and the way to find undiagnosed complications should be investigated in the differential diagnosis of other diseases. results most of the patients (73.8%) were in the acute stages of brucellosis, 22.6% had sub-acute brucellosis and 3...

BACKGROUND Short-term particulate air pollution exposure is associated with reduced heart rate variability (HRV), a risk factor for cardiovascular morbidity and mortality, in many studies. Associations with sub-chronic or long-term exposures, however, have been sparsely investigated. We evaluated the effect of fine particulate matter (PM2.5) and black carbon (BC) exposures on HRV in an elderly ...

We contrasted the neuroanatomical substrates of sub-acute and chronic visuospatial deficits associated with different aspects of unilateral neglect using computed tomography scans acquired as part of routine clinical diagnosis. Voxel-wise statistical analyses were conducted on a group of 160 stroke patients scanned at a sub-acute stage. Lesion-deficit relationships were assessed across the whol...

This study investigated factors associated with long-term use of benzodiazepines (BZDs) or benzodiazepine receptor agonists (BzRAs) as hypnotics in patients with chronic insomnia. Consecutive patients (n = 140) with chronic insomnia were enrolled in this study (68 men and 72 women; mean age, 53.8 ± 10.8 years). All patients filled out a self-assessment questionnaire asking clinical descriptive ...

saffron (crocus sativus l.) has been considered as a medicinal plant since ancient times and also widely used as food additive for its color, taste and odor. the pharmacological properties of saffron and its main constituents, crocin and safranal have been evaluated using different in vivo and in vitro models. additionally, other lines of studies have found toxicological effects of saffron.  ho...

the potential changes in neuromuscular blockade after chronic (>24 h) administration of sub-paralytic doses of two newly introduced aminosteroidal muscle relaxants were investigated. org-9426 (rocuronium) and org-9487 were studied in the in vivo guinea pig gastrocnemius muscle-sciatic nerve preparation. the problems seen after prolonged administration of muscle relaxants are thought to arise fr...