Critically ill patients are at risk for stress ulcers in the upper digestive tract. Various factors have been associated with this condition. Patients who critically of bleeding due to related mucosal disease (SRMD). Upper gastrointestinal tract problems usually occur as a result severe physiological stress. may develop gastric erosion and which can be fatal. Routine pharmacological use ulcer p...

Background: Stress-related mucosal disease (SRMD) frequently develops in critically ill patients, increasing mortality and length of intensive care unit (ICU) stay. There is limited data on stress ulcer prophylaxis (SUP) patients Indonesia.Objective:Methods: This a retrospective cohort study admitted to the ICU from January 1, 2015, December 31, 2017. The subjects were all who used proton pump ...

Mitchell J. Spirt is an assistant clinical professor of medicine in the Division of Gastroenterology, University of California, Los Angeles School of Medicine, Los Angeles, Calif, and is the chief of gastroenterology at Century City Doctors Hospital in Century City, Calif. Sandra Stanley is a gastrointestinal staff nurse at the Specialty Surgical Center in Beverly Hills, Calif. Optimal manageme...

Background Stress-related gastric ulceration was first described in the early 1970s, and has since received extensive study. Appreciation of the physiologic changes that promote stress-related gastritis and general improvements in the care of critically ill patients have likely played a role in reducing the frequency of this complication. Nonetheless, the use of specific pharmacologic agents fo...

The effect of rebamipide, a mucosal protective drug, on small intestinal mucosal injury caused by indomethacin was examined using a rat model. Indomethacin administration (10 mg/kg, p.o.) induced intestinal mucosal injury was accompanied by an increase in the numbers of intestinal bacteria particularly Enterobacteriaceae in the jejunum and ileum. Rebamipide (30 and 100 mg/kg, p.o., given 5 time...

Adding proton pump inhibitors (PPIs) to endoscopic therapy has become the mainstay of treatment for peptic ulcer bleeding, with current consensus guidelines recommending high-dose intravenous (IV) PPI therapy (IV bolus followed by continuous therapy). However, whether or not high-dose PPI therapy is more effective than low-dose PPI therapy is still debated. Furthermore, maintaining pH ≥ 4 appea...