The aim of the present study was to evaluate antidiabetic activity ethanol extract leaves Flax plant (Linum usitatissimum) in streptozotocin (STZ) induced diabetic rats. Ethanol Linum usitatissimum (EELL) or glibenclamide administered rats orally daily for 28 days. Blood glucose levels at weekly interval and on 29th day, serum biochemical parameters were carried out its effect glucose, creatini...

We have evaluated the influence of oligofructose (OFS), a fermentable dietary fibre, on glucose homeostasis, insulin production and intestinal glucagon-like peptide-1 (GLP-1) in streptozotocin-treated diabetic rats. Male Wistar rats received either i.v. streptozotocin (STZ; 40 mg/kg) or vehicle (CT); one week later, they were fed for 6 weeks with either the standard diet (STZ-CT), or with a die...

We previously prepared ophthalmic formulations containing cilostazol (CLZ) nanoparticles by bead mill methods (CLZnano), and found that instillation of CLZnano into rat eyes supplies CLZ into the retina. In this study, we investigated changes in the electroretinograms (ERG) of streptozotocin-induced diabetic rats (STZ rats), a model of diabetes mellitus. In addition, we demonstrated that disper...

Purpose: To investigate the neuroprotective effect of natural flavonoid rhoifolin in rats with streptozotocin (STZ)-induced (AD).
 Methods: Morris water-maze and novel object recognition tests were carried out to estimate on memory cognition. Histopathological analysis was made observe thickness hippocampal CA1 pyramidal layer. Analysis oxidative stress markers performed hippocampus fronta...

Accumulating evidence indicates the association between changes in circulating sex steroid hormone levels and development of diabetic nephropathy. However, renal synthesis hormones during diabetes is essentially unknown. Male Wistar rats were injected with streptozotocin (STZ) or vehicle. After one week, no functional structural parameters related to kidney damage observed STZ group; however, a...

Objectives: The study is planned to investigate the antidiabetic activity of hesperidin on Streptozotocin (STZ)-induced diabetes mellitus in Swiss Albino mice. Materials and Methods: mice were divided into six groups viz., normal control, diabetic insulin 0.75 IU/kg, 100, 200 400 mg/kg, respectively (n = 6/group). All received treatments once daily for 21 consecutive days, except control groups...

With the rising prevalence of diabetes mellitus around world, researchers have been searching for a new treatment option that is both more effective and safer than chemotherapy. This study evaluated antidiabetic activities aqueous extracts Eclipta prostrataL. in streptozotocin (STZ)-induced diabetic rats. The rats were randomized into six groups: Normal control, STZ-induced (50 mg/kg), STZ + EP...

In this work, it has been attempted to determine the alterations brought about in the enzyme activities by oral administering acetone, isopropanol and ethanol to chemically induced diabetic rats. The rats in whom diabetes was induced diabetic by 65 mg/kg streptozotocin (stz) were divided into four main groups as a stz alone (group I), stz + aceton (group II), stz + isopropanol (group III), stz ...

In this study, it was investigated of the effect Polygonum cognatum Meissn. ethanol extract Bax, Bcl-2, Caspase-3, NF-kB and NRF-2/HO-1 pathways in streptozotocin induced diabetic rats. A total 24 healthy Spraque-Dawley male rats were randomly divided into four groups containing 6 per group as Control; Diabetes mellitus (DM); (PCE) DM+PCE. Experimental diabetes by a single dose 60 mg/kg/i.p Str...