paliurus spina-christi mill (rhamnaceae) has been used in folk medicine as a hypocholesterolemic agent. in this study, the effect of total fruit extract on lowering lipid content of serum was investigated. male rats were introduced streptozocin, subsequently fed with a high cholesterol diet and concomitantly treated with various doses of the extract. after 8 days, serum levels of cholesterol, t...

BACKGROUND Left ventricular (LV) dysfunction is closely associated with LV hypertrophy or diabetes, as well as insufficient autophagic flux. Acute or chronic hyperglycemia is a prognostic factor for patients with myocardial infarction. However, the effect of acute hyperglycemia on LV dysfunction of the hypertrophic heart and the mechanisms involved are still unclear. This study aimed to confirm...

BACKGROUND Diabetic cardiomyopathy (DMCMP) is characterized by myocardial dysfunction regardless of coronary artery disease in diabetic patients. The features of LV dysfunction in rat model of type 1 DM induced by streptozocin, are variable and controversial. Thus, we tested the usefulness of tissue Doppler imaging in the early detection of ventricular dysfunction in a rat model of DMCMP. MET...

diabetes mellitus (dm) is one of the most important metabolic disease causes in many side effects. the decrease of mental abilities and even some form of dementia followed prolonged diabetes has been reported. there are evidences that show hippocampus might be the site of neural involvement in patients with dementia followed diabetes. as hippocampus received main serotonergic efferents from bra...

conclusions oral mg supplementation did not protect the cp induced nephrotoxicity in diabetic rats. results cp administration in normoglycemic rats significantly elevated the serum levels of blood urea nitrogen (bun) and creatinine (cr) (p < 0.05). however, coadministration of cp and mg statistically increased the serum levels of bun and cr in both normoglycemic and diabetic animals when compar...

background: diabetes mellitus is considered one of the 5 principal causes of death in the world and is recognized as a global public health issue because of its multifactorial facets affecting essential biochemical processes in the body. this study investigated the antidiabetic and antidyslipidemic activities of the aqueous extract of cochlospermum planchonii (c. planchonii) leaves in streptozo...

evaluation of hypoglycemic activity of inflorescence of borassus flabellifer extract in male wistar rats has been investigated. antidiabetic potentials were studies by the orally administration of plant extract at the doses of 150, 300 and 600 mg/kg in streptozocin-induced diabetic male wistar rats. treatment of streptozocin-induced diabetic male wistar rats with the extracts caused a significa...

The present study examines the effect of combinations of gabapentin (Neurontin) and a selective neurokinin (NK)(1) receptor antagonist, 1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-[(1-phenylethyl)amino]ethyl]-2-benzofuranylmethyl ester (CI-1021), in two models of neuropathic pain. Dose responses to both gabapentin and CI-1021 were performed against static allodynia induced in the streptozocin and ...