OBJECTIVES To describe the efficacy, safety, and exposure-response relationship of canakinumab in a subgroup of patients with systemic juvenile idiopathic arthritis (SJIA) aged ≥16 years, representative of adult-onset Still's disease (AOSD) patients, and to compare this subgroup with those of children and young adolescents with SJIA by pooling clinical data collected during the development prog...

Introduction The greater part of the literature on the occurrence of amyloidosis in rheumatoid arthritis and in Still's disease comes from the Western Hemisphere. Since the recent publication in this country of such a case by Yeoman and Wilson (1947) the interest of rheumatologists on this side of the Atlantic has been awakened and a watch has been kept for further cases. Over 200 cases of rheu...

Parents of 135 children with juvenile rheumatoid arthritis (JRA) completed a mailed questionnaire about problems at school. Writing was the most frequently reported difficulty, with hand involvement causing more problems than decreased mobility. Compared to children with pauciarticular JRA, those with polyarticular or systemic JRA were significantly more likely to miss school, experience proble...

PURPOSE Preferences of both Alzheimer patients and their spouse caregivers are related to a willingness-to-pay (WTP) measure which is used to test for the presence of mutual (rather than conventional unilateral) altruism. METHODOLOGY Contingent valuation experiments were conducted in 2000-2002, involving 126 Alzheimer patients and their caregiving spouses living in the Zurich metropolitan are...

We describe a 16 year old patient who developed Still's disease with evidence of myocarditis. A rise in the mumps 'V' antigen indicated that the disease was associated with recent mumps infection.

The Maximum Density Sill-Life Problem is to fill an n × n board of cells with the maximum number of live cells so that the board is stable under the rules of Conway’s Game of Life. We reformulate the problem into one of minimising “wastage” rather than maximising the number of live cells. This reformulation allows us to compute strong upper bounds on the number of live cells. By combining this ...

BACKGROUND Primary jejunal gastrinomas are exceedingly rare, and data for long-term follow-up is limited. Until now, only six cases of gastrinomas arising from the jejunum have been reported in the English literature. CASE PRESENTATION Presented is a case of a primary gastrinoma located in the proximal jejunum. After surgical resection of the tumor, eugastrinemia was quickly achieved and afte...

To the editor: The recent report by Muscat et al., on the 2009 to 2011 measles outbreak in Bulgaria, emphasised that this infectious disease still represents a health issue of concern that can re-emerge with a substantial magnitude in Europe [1]. Indeed, this epidemiological analysis recorded 24,364 cases in Bulgaria between April 2009 and December 2011 and, importantly, around 73% of those inf...

The relationship between diet and the development of chronic disease still remains a controversial area. One major difficulty is to obtain a valid estimate of habitual pattern and level of food consumption for each individual. There is, in fact, a voluminous and largely negative literature on the validity of dietary assessment methods. In the present paper the utility of the most frequently use...