Monoaryloxide-pyrrolide (MAP) complexes of molybdenum were employed for the selective ethenolysis of 1,2-disubstituted Z olefins in the presence of the corresponding E olefins. Reactions were performed in the presence of 0.02-3.0 mol % catalyst at 22 °C under 20 atm ethylene. We have demonstrated that the Z isomer of an easily accessible E:Z mixture can be destroyed through ethenolysis and the ...

The cholesteric twist inversion by temperature variation of a single component thermotropic liquid crystalline system was experimentally investigated and is explained by the partial twisting power model, evaluating the temperature dependent pitch of five different configurations of a benzoic acid biphenyl ester with two chiral centers. The temperature dependence of the twisting power and the ch...

Structural modifications of natural products with complex structures like steroids require great synthetic effort. A review of literature is presented on the chemistry of the steroidal hormone 17α-methyltestosterone that is approved by Food and Drug Administration (FDA) in the United States as an androgen for estrogen-androgen hormone replacement therapy treatment. The analog also offers specia...

The two geometric isomers of 2-(tert-butyl)-4-phenyloxetane have, for the first time, been prepared starting from the commercially available 4,4-dimethyl-1-phenylpentane-1,3-dione. The latter was reduced with NaBH4 to give a mixture of diastereomeric syn and anti diols which were then stereospecifically cyclized into the corresponding oxetanes with an overall yield for the two steps of 69.6%. T...

[structure: see text]. trans-4-hydroxynonenal (4-HNE) is a unique product from the peroxidation of omega-6 polyunsaturated fatty acids. The major reaction of racemic 4-HNE with DNA is with deoxyguanosine to give four stereoisomeric exocyclic propano adducts. The stereospecific syntheses of these four adducts has been achieved at the nucleoside level. The synthetic approach is amenable to the sy...

Background: Naturally extracted trans-(−)-kusunokinin from P. nigrum showed anticancer activities via binding and inhibition of CSF1R. However, the synthetic racemic mixtures trans-(−)- trans-(+)-kusunokinin (trans-(±)-kusunokinin) exhibited different effects on breast cancer cell lines. It was hypothesized that trans-(±)-kusunokinin bind to additional molecules, including AKR1B1. Previously, w...