Lowering serum lipid levels is part of the foundation of treating and preventing clinically significant cardiovascular disease. Recently, the American Heart Association/American College of Cardiology released cholesterol guidelines which advocate for high efficacy statins rather than LDL-c goals for five patient subgroups at high risk for cardiovascular disease. Therefore, it is critical that c...

Statins, among the most commonly prescribed drugs worldwide, are cholesterol-lowering agents used to manage and prevent cardiovascular and coronary heart diseases. Recently, a multifaceted action in different physiological and pathological conditions has been also proposed for statins, beyond anti-inflammation and neuroprotection. Statins have been shown to act through cholesterol-dependent and...

Dyslipidemia and chronic inflammation may play a role in the cause of lower urinary tract symptoms (LUTS) in older men. Use of statin drugs, which are prescribed to lower cholesterol and appear to reduce inflammation, may decrease the incidence or progression of LUTS. The associations of statin drug use with LUTS incidence and progression were prospectively evaluated in the Health Professionals...

Ichthyosis is a heterogeneous group of hereditary or acquired skin disorders, characterized by increased stratum corneum production. Several systemic diseases and many drugs can occasionally cause acquired ichthyosis. We report a case of statin-induced ichthyosis in which the causality between statin and ichthyosis was found possible by using the Naranjo scale. A 79-year-old woman presented wit...

In this section we report statin usage rates and compare trends in observables over the entire population covered in our claims database who fit at least one of the criteria defined as risk factors for statin usage: above age 45 (if male) or 55 (if female), hypertension, diabetes, or cardiac disease. If physicians responded to Zocor’s patent expiration by prescribing statins more broadly, to pa...

INTRODUCTION Statins reduce risk of cardiovascular events and have beneficial pleiotropic effects; both may reduce mortality in critically ill patients. We examined whether statin use was associated with risk of death in general intensive care unit (ICU) patients. METHODS Cohort study of 12,483 critically ill patients > 45 yrs of age with a first-time admission to one of three highly speciali...

Manual therapists, confronted by patients complaining of chronic muscular pain, need to be aware of a possible source of that pain e their patient’s medication, particularly if statins are being taken. One of the main reported side effects of statin consumption involves development of the symptoms of myopathy. This is confirmed by both past and recent research (Fernandez et al., 2011; Sathasiva...

STATIN-INDUCED MYOPATHY Statins are associated with a known risk of muscle-related symptoms, which are the most common adverse effects of statin drugs. Myopathy is a general term for muscle toxicity. Three categories of statin-induced myopathy have been defined by a joint committee of the American College of Cardiology, American Heart Association, and National Heart, Lung and Blood Institute: ...

Muscle problems and other adverse symptoms associated with statin use are frequent reasons for non-adherence and discontinuation of statin therapy, which results in inadequate control of hyperlipidemia and increased cardiovascular risk. However, most patients who experience adverse symptoms during statin use are able to tolerate at least some degree of statin therapy. Given the profound cardiov...

BACKGROUND Cholesterol management drugs known as statins are widely used and often well tolerated; however, a variety of muscle-related side effects can arise. These adverse events (AEs) can have serious impact, and form a significant barrier to therapy adherence. Surveillance of post-marketing AEs is of vital importance to understand real-world AEs and reporting differences between individual ...