The aberrantly expressed signal transducer and activator of transcription 3 (STAT3) predicts poor prognosis, primarily in estrogen receptor positive (ER(+)) breast cancers. Activated STAT3 is overexpressed in luminal A subtype cells. The mechanisms contributing to the prognosis and/or subtype relevant features of STAT3 in ER(+) breast cancers are through multiple interacting regulatory pathways...

Abstract We have previously shown that the transmembrane protein ODZ1 serves for glioblastoma (GBM) cells to invade surrounding tissue through activation of RhoA/ROCK pathway. However, transcriptional machinery used by GBM regulate expression is unknown. Here we show interaction with tumor microenvironment elements, mainly activated monocytes IL-6 secretion, and extracellular matrix fibronectin...

While signal transducers and activators of transcription (STATs) were originally discovered as intracellular effectors of normal signaling by cytokines, increasing evidence also points to a role for STAT transcription factors in oncogenesis. Previous studies have demonstrated that one STAT family member, Stat3, possesses constitutively elevated tyrosine phosphorylation and DNA-binding activity ...

TPX2, a protein involved in mitosis, is considered a good marker for actively proliferating tissues, highly expressed in a number of cancer cells. We show the presence of high-affinity binding site for STAT3 in the 5'-flanking region of the Tpx2 gene, which is in vivo bound by activated STAT3. A specific STAT3 peptide inhibitor represses the expression of the Tpx2 gene and inhibits the binding ...

Electroacupuncture (EA) can help reduce infarct size and injury resulting from myocardial ischemia/reperfusion (I/R); however, the underlying molecular mechanism remains unknown. We previously reported that STAT5 plays a critical role in cardioprotective effect of remote ischemic preconditioning (RIPC). Here, we assessed effects electroacupuncture pretreatment (EAP) on I/R presence and/or absen...

To study the significance of signal transducer and activator of transcription (Stat) 3 in lung epithelial development of fetal mice, we examined fetal mouse lungs, focusing on the expression of Clara cell secretory protein (CCSP), Forkhead box protein J1 (Foxj1), calcitonin gene-related peptide (CGRP), phosphorylated Stat3 (Tyr705), and hairy/enhancer of split (Hes) 1, and observed cultured fet...

The generation of high-affinity antibodies and the development of B cell memory are dependent on the help provided by CD4 T cells. Mouse studies indicate that STAT3 signaling in CD4 T cells promotes the acquisition of the B cell help function. However, the role of STAT3 in humans has been controversial. In this study, we show that IL-6 and other STAT3 activating cytokines (IL-21 and IL-27) indu...

Abstract p27 normally inhibits cell cycle progression and growth. In cancers, deregulated acts as an oncogene to promote metastasis when phosphorylated by PI3K-activated kinases at T157 T198 (p27pTpT). We showed p27pTpT transcriptionally co-activates cJun induces STAT3 activation. Here, we pursue the hypothesis that target genes expand cancer stem cells (CSC) inflammation. triple negative breas...

Aortic dissection (AD) is a medical emergency, in which acute destruction of aortic wall occurs with unknown etiology. Recent studies have uncovered the critical role inteleukin-6 (IL-6) and inflammatory cells including macrophages disease mechanism AD. IL-6 activates janus kinase signal transducer activator transcription 3 (STAT3) to alter gene expression program many cell types, thus regulati...