OBJECTIVES To compare narrowband UV-B (TL-01 lamp) phototherapy for psoriasis with individual patient starting doses based on minimal erythemal dose (MED) determination vs a standard fixed starting dose and to compare the efficacy of 70% of MED vs 50% of MED starting dose regimens. DESIGN Single-center, randomized, double-blind, clinical trial. SETTING Department of Dermatology, Ninewells H...

starting treatment of chronic indolent conditions at doses lower than those typically recommended in the product monographs. The approach we recommend is to use a very low dose when starting a new medication if the condition is not life-threatening or producing severe symptoms. Unfortunately, this approach is not used that much in practice. First, we should define “very low dose.” The “start lo...

PURPOSE Nanoparticles or carrier-mediated agents have been designed to prolong drug circulation time, increase tumor delivery, and improve therapeutic index compared to their small-molecule counterparts. The starting dose for phase I studies of small molecules and nanoparticles anticancer agents is based on the toxicity profile of the most sensitive species (e.g., rat or canine), but the optima...

Abstract Background: Mifepristone is an antiprogesterone that has been studied in females and shown central effects including suppressing LH surges. There a paucity of information about how it males. Clinical Case: 65-year-old male with bilateral adrenal macronodular hyperplasia noted on past surveillance CT scan presented to endocrinology. He had history coronary artery disease, type 2 diabete...