OBJECTIVE This study looks to compare the antidepressant efficacy and safety of a standardized extract of St John's wort with both placebo and fluoxetine. METHOD After a 1-week single-blind washout, patients with major depressive disorder diagnosed by Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition were randomized to 12 weeks of double-b...

This article reviews the historical background, active ingredients of St. John's Wort and the major double-blind placebo-controlled studies. Despite the two major failed clinical trials conducted in American Research Centers, most of the data reviewed support that hypericum extracts are more effective than placebo for the treatment of mild to moderate depressive illness. The authors examine the...

PURPOSE This study examined the effects of hypohydration and moderate hyperthermia (core temperature elevation) on anaerobic exercise performance in a temperate environment. METHODS Eight active males completed two passive heat exposure trials (180 min, 45 degrees C, 50% rh) with (EUH) and without (HYP) fluid replacement. A single 15-s Wingate anaerobic test (WAnT) was used to assess anaerobi...

St. John's Wort scientifically known as Hypericum Perforatum, an herbal remedy generally used to treat depression, is making a rise throughout Europe and the United States. St. John's Wort is a perennial plant that produces abundant yellow flowers and grows naturally throughout much of the world, including specifically in northern California, southern Oregon, and Colorado. It usually flowers on...

Jovis Johny1, Partha Sarathi Sarkar2, Deepali Saxena3, Babu Philip4 1Post-graduate Resident, Department of Radiology, ST. Johns Hospital, Bengaluru, Karnataka, India, 2Senior Resident, Department of Radiology, ST. Johns Hospital, Bengaluru, Karnataka, India, 3Associate Professor, Department of Radiology, ST. Johns Hospital, Bengaluru, Karnataka, India, 4Professor, Department of Radiology, ST. J...

Herbs, vitamins, and other dietary supplements may augment or antagonize the actions of prescription and nonprescription drugs. St. John's wort is the supplement that has the most documented interactions with drugs. As with many drug-drug interactions, the information for many dietary supplements is deficient and sometimes supported only by case reports. Deleterious effects are most pronounced ...