The expression of the recently described steroid receptor RNA activator (SRA) was measured by semiquantitative reverse transcription-PCR within 27 independent breast tumors, spanning a wide spectrum of grade and estrogen receptor (ER) and progesterone receptor (PR) levels. Subgroup analysis showed that SRA expression was similar in ER+/PR+ (median = 65.5, n = 8) and in ER-/PR- (median = 94.6, n...

The NCBI now maintains the Short Read Archive (SRA) (www.ncbi.nlm.nih.gov/Traces/ sra/) as a repository for data from sequencing projects that use the new massively parallel sequencing technologies, often called next-generation sequencing. These methods can generate hundreds of megabases to gigabases of data in a single instrument run, millions of times the output of a standard Sanger sequencin...

INTRODUCTION Short Root Anomaly (SRA) is an uncommon disease and a challenge for orthodontic treatment as it tends to increase the risk of root resorption. OBJECTIVE Assess the current status of the diagnosis, etiology and orthodontic management of teeth with SRA, and present case reports. METHODS A literature review was carried out in PubMed, SciELO, LILACS, Scopus and Web of Science datab...

Simultaneous reachability analysis (SRA) is a recently proposed approach to alleviating the state space explosion problem in reachability analysis of concurrent systems. The concept of SRA is to allow a global transition in a reachability graph to contain a set of transitions of di erent processes such that the state reached by the global transition is independent of the execution order of the ...

Long non-coding RNAs (lncRNAs) have been recognized as key players in transcriptional regulation. We show that the lncRNA steroid receptor RNA activator (SRA) participates in regulation through complex formation with trithorax group (TrxG) and polycomb repressive complex 2 (PRC2) complexes. Binding of the SRA-associated RNA helicase p68 preferentially stabilizes complex formation between SRA an...

Sink location protection is critical to the viability of sensor networks as the central point of failure. Most existing work related to sink location protection focuses on local traffic analysis attack. In this paper, we study the sink location protection problem under a more powerful type of attack, the global traffic analysis attack. In order to hide the sink location, a protocol based on pac...

We have recently shown that the non-coding RNA, steroid receptor RNA activator (SRA), functions as a transcriptional coactivator of PPARγ and promotes adipocyte differentiation in vitro. To assess SRA function in vivo, we have generated a whole mouse Sra1 gene knock-out (SRA(-/-)). Here, we show that the Sra1 gene is an important regulator of adipose tissue mass and function. SRA is expressed a...

Sleep is a fundamental biological process for all animals. However, the molecular mechanisms that regulate sleep are still poorly understood. Here we report that sleep-like behavior in Drosophila is severely impaired by mutations in sarah (sra), a member of the Regulator of Calcineurin (RCAN) family of genes. Sleep reduction in sra mutants is highly correlated with decreases in Sra protein leve...

Peroxisome proliferator-activated receptor-γ (PPARγ) is a master transcriptional regulator of adipogenesis. Hence, the identification of PPARγ coactivators should help reveal mechanisms controlling gene expression in adipose tissue development and physiology. We show that the non-coding RNA, Steroid receptor RNA Activator (SRA), associates with PPARγ and coactivates PPARγ-dependent reporter gen...