accumulating evidence suggests that self-renewal and differentiation capabilities reside only in a subpopulation of tumor cells, termed cancer stem cells (cscs), whereas the remaining tumor cell population lacks the ability to initiate tumor development or support continued tumor growth. in head and neck squamous cell carcinoma (hnscc), as with other malignancies, cscs have been increasingly sh...

the association of squamous cell carcinoma of the larynx with thyroid papillary carcinoma is an unusual finding. from 2004 to 2011, approximately 250 patients underwent laryngectomies due to squamous cell carcinoma of the larynx at the otolaryngology department of khalili hospital, affiliated with shiraz university of medical sciences, shiraz, iran. in three patients, synchronous occurrence of ...

Introduction: Head and neck squamous cell carcinoma (HNSCC) is one of the most common cancers in the world. Extra- and intra-cellular high-mobility motor box 1 (HMGB1) proteins are invovled in the pathogenesis and prognosis of cancer. Regarding this, the present study was conducted with the aim of investigating the expression of HMGB1 protein and mRNA levels in the blood, tumor tissue, and mar...

background: epidemiologic and molecular evidences have established a strong link between high risk types of human papilloma virus and a subgroup of head and neck squamous cell carcinomas (hnscc). we evaluated the frequency of hpv positivity in hnscc and its relationship to demographic and some risk factor variables in an open case- control study. methods: fourteen recently diagnosed patients wi...

While vitamin D exhibits a multitude of cellular effects that can impact on cancer development and progression, this review focuses on its immune modulatory effects. These immune modulatory effects can be both direct and indirect. Compared to other cancer types, head and neck squamous cell carcinomas (HNSCC) have received less attention, but are a fascination immunologically because of the prof...

Background and purpose: Cancer is highly prevalent in modern societies and approximately one in three or four people is diagnosed with cancer. Oral cancer is one of the 10 primary causes of mortality due to late detection for many reasons, including being asymptomatic in initial stages, clinical presentation similar to other lesions, and variation in clinical manifestations. This study aimed at...

statement of the problem: the head and neck region is an uncommon site for metastatic involvement, but it can be the first and only symptom of primary cancer. the incidence of these tumors and their primary origins are limited in iranian patients. purpose: therefore, this retrospective study aimed to investigate the frequency and the common related clinical manifestations, as well as, the most ...

Comprehensive identification of potential immune-related genes related to tumor biological behavior and their significance in the treatment head neck squamous cell carcinoma with a messenger RNA (mRNA) vaccine

Background & Objective: Laryngeal squamous cell carcinoma (LSCC) is considered to be one of the most common cancers of the head and neck, accounting for roughly 90% of all malignant tumors of the larynx. To have a timely diagnosis for a better and practical therapy, molecular markers have to be investigated. The aim of this study was to determine the expression of Cyclin D1 (CD...

Background: Squamous cell carcinoma has a wide range of histological differentiation, which indicates the prognosis. Location of the tumor also affects its prognosis. Objective: To determine the relationship between location of the tumor, age and sex of patients and histological grading of it. Patients and Methods: In this retrospective study, 44631 files of the patients who were referred to tw...