Synthetic substrates that mimic the properties of extracellular matrix proteins hold significant promise for use in systems designed for tissue engineering applications. In this report, we designed a synthetic polymeric substrate that is intended to mimic chemical, mechanical, and topological characteristics of collagen. We found that elastomeric poly(ester amide) substrates modified with repli...

In the last decade, temporal networks and static hypergraphs have enabled modelling connectivity spreading processes in a wide array of real-world complex systems such as economic transactions, information spreading, brain activity disease spreading. this manuscript, we present Reticula C++ library Python package: A comprehensive suite tools for working with synthetic hypergraphs. This includes...

Using synthetic peptides, we have identified two distinct regions of the glycoprotein SPARC (Secreted Protein Acidic and Rich in Cysteine) (osteonectin/BM-40) that inhibit cell spreading. One of these sites also contributes to the affinity of SPARC for extracellular matrix components. Peptides representing subregions of SPARC were synthesized and antipeptide antibodies were produced. Immunoglob...

Victor M. Preciado∗ and Ali Jadbabaie† Department of Electrical and Systems Engineering University of Pennsylvania, Philadelphia, PA 19104‡ Abstract The intricate structure of many large-scale networked systems has attracted the attention of the scientific community, leading to many results attempting to explain the relationship between network structural properties and dynamical performance. A...

By modeling synthetic Pn amplitudes in 2007, my colleagues and I proposed a Pn geometric-spreading model (Y2007) that takes into account the spherical shape of the Earth. In this study, we used a set of observed Pn amplitudes from the tectonically active regions of Asia to evaluate the performance of Y2007 and to develop new, observation-based Pn spreading models. Even though Y2007 provides imp...

Exploring the interplay between information spreading and epidemic spreading is a topic that has been receiving increasing attention. As an efficient means of depicting the spreading of information, which manifests as a cascade phenomenon, awareness cascading is utilized to investigate this coupled transmission. Because in reality, different individuals facing the same epidemic will exhibit dis...

The identification of the most influential spreaders in networks is important to control and understand the spreading capabilities of the system as well as to ensure an efficient information diffusion such as in rumor-like dynamics. Recent works have suggested that the identification of influential spreaders is not independent of the dynamics being studied. For instance, the key disease spreade...

To investigate how cells sense stiffness in settings structurally similar to native extracellular matrices (ECM), we designed a synthetic fibrous material with tunable mechanics and userdefined architecture. In contrast to flat hydrogel surfaces, these fibrous materials recapitulated cell-matrix interactions observed with collagen matrices including stellate cell morphologies, cellmediated real...

In most social and information systems the activity of agents generates rapidly evolving time-varying networks. The temporal variation in networks' connectivity patterns and the ongoing dynamic processes are usually coupled in ways that still challenge our mathematical or computational modelling. Here we analyse a mobile call dataset and find a simple statistical law that characterize the tempo...