The aims of this research were first, to evaluate the antibacterial potential of commercial thyme essential oil against V. alginolyticus and V. parahaemolyticys and second, using the spray drying technique to produce microcapsules. chemical compounds of thyme oil and microcapsules were identified and quantified being thymol the chemical component present at the highest concentration. Oil-in-wat...

in this study, blueberry essential oil as a core material was microencapsulated with inulin and β-cyclodextrin at a ratio of 1:5 (core: wall). oil in water nano-emulsions were prepared by ultrasonic liquid processors and then transformed to encapsulate powder in spray dryer. dried powder was stored at 4 ˚c in refrigerator for determining moisture, encapsulation efficiency and morphology prop...

Spray drying is a common unit operation across many industries due to the ability to control bulk powder properties and isolate dry product from a liquid feed in a single operation. For the pharmaceutical industry, spray drying offers the control of physical properties of crystalline or amorphous active pharmaceutical ingredients (APIs), as a neat or formulated drug product that can lead to imp...

A numerically effective approach was developed for the modeling of spray-drying colloidal suspensions. This based on integration two models. The first is a phenomenological and radially symmetric model accounting drying single-droplets, while second employs computational fluid dynamics (CFD) simulations to account gas flow conditions atomization in spray dryer. Experiments were also conducted s...

The present study investigated the effect of operating parameters of a laboratory spray dryer on powder characteristics, in order to optimise the production of trehalose and raffinose powders, intended to be used as carriers of biomolecules for inhalation. The sugars were spray dried from 80:20 methanol:n-butyl acetate (v/v) solutions using a Büchi Mini Spray dryer B-290. A 2(4) factorial desig...

The local delivery of antibiotics in the treatment of infectious respiratory diseases is an attractive alternative to deliver high concentration of antimicrobials directly to the lungs and minimize systemic side effects. In this study, inhalable microparticles containing doxycycline hyclate, sodium carboxymethylcellulose, leucine and lactose were prepared by spray drying of aqueous ethanol form...

Early development drug formulation is exacerbated by increasingly poor bioavailability of potential candidates. Prevention of attrition due to formulation problems necessitates physicochemical analysis and formulation studies at a very early stage during development, where the availability of a new substance is limited to small quantities, thus impeding extensive experiments. Miniaturization of...

Spray-drying was chosen as an appropriately scalable manufacturing method to dry cellulose nanofibril (CNF) suspensions. Spray-drying of two different types of CNF suspensions—nanofibrillated cellulose (NFC) and cellulose nanocrystals (CNC)—was carried out using a laboratory-scale spray dryer. Effects of three spray-drying process parameters on particle morphology and particle size distribution...