Male and female Sprague-Dawley rats reared in social isolation and in crowded conditions were tested on their active-avoidance performance. Only males appeared to be affected by the treatments; no housing-condition effect was found on the performance of females. The most severe housing-condition effect was that of social isolation; the isolated males showed impaired acquisition of the avoidance...

Male Sprague-Dawley rats ranging in age from 20 to 110 days were injected with two doses of morphine sulphate, and examined for behavioral activation and catalepsy. Behavioral activation increased with age, while sensitivity to catalepsy declined. Ontogenetic and pharmacological responses suggest possible separate mediation of activation and catalepsy.

We examine the Sprague-Grundy values of the game of R-Wythoff, a restriction of Wythoff’s game introduced by Ho, where each move is either to remove a positive number of tokens from the larger pile or to remove the same number of tokens from both piles. Ho showed that the P -positions of R-Wythoff agree with those of Wythoff’s game, and found all positions of Sprague-Grundy value 1. We describe...

BACKGROUND Hematologic and biochemical analytes of Sprague-Dawley rats are commonly used to determine effects that were induced by treatment and to evaluate organ dysfunction in toxicological safety assessments, but reference intervals have not been well established for these analytes. Reference intervals as presently defined for these analytes in Sprague-Dawley rats have not used international...

In the study of tissues that contain several forms of one cytochrome P450 subfamily, it is useful to develop immunoblotting techniques so that the various individual members of the family can be distinguished. This paper describes improvements in the immunoblotting technique to distinguish members of the rat cytochrome P450 4A subfamily, 4A1, 4A2, and 4A3, as they are present in Sprague-Dawley ...

We examine the Sprague-Grundy values of F-Wythoff, a restriction of Wythoff’s game introduced by Ho, where the integer ratio of the pile sizes must be preserved if the same number of tokens is removed from both piles. We answer two conjectures raised by Ho. First, we show that each column of Sprague-Grundy values is ultimately additively periodic. Second, we prove that every diagonal of Sprague...

RATIONALE MDMA alters body temperature in rats with a direction that depends on the ambient temperature (TA). The thermoregulatory effects of MDMA and TA may affect intravenous self-administration (IVSA) of MDMA but limited prior reports conflict. OBJECTIVE To determine how body temperature responses under high and low TA influence MDMA IVSA. METHODS Male Sprague-Dawley rats were trained to...