نتایج جستجو برای: spot hrg
تعداد نتایج: 37066 فیلتر نتایج به سال:
PURPOSE We sought to gain insight into the mechanisms of heregulin-beta1 (HRG) action on breast epithelial cells by identifying and characterizing HRG-regulated proteins. EXPERIMENTAL DESIGN Differential display mRNA screening of human breast cancer cells grown in the presence or absence of HRG was used to identify HRG-regulated genes. Biochemical and functional studies were undertaken to exa...
جنگل¬ها بزرگ¬ترین منبع ذخایر کربن در اکوسیستم¬های زمینی هستند. با این حال، به دلیل ساختار پیچیده و وسعت جنگل¬ها، برآورد دقیقی از ذخایر کربن جنگل¬ها در دست نیست. نظارت بر جنگل¬ها با استفاده از تصاویر ماهواره¬ای در چند دهه¬ی اخیر، به¬جایی رسیده است که این مجموعه داده¬ها به¬عنوان اطلاعات جهت سیاستگذاری¬های بین¬المللی، به¬طور قابل توجهی در ارتباط با میزان انتشار دی¬اکسید کربن موجود در اتمسفر ناشی ا...
Title of Document: IDENTIFICATION AND CHARACTERIZATION OF HRG-1 HEME TRANSPORTERS IN EUKARYOTES Abbhirami Rajagopal, Doctor of Philosophy, 2008 Directed By: Assistant professor Dr. Iqbal Hamza, Department of Animal and Avian sciences & Molecular and Cellular Biology Program (MOCB) Heme is a prosthetic group in proteins that perform diverse biological functions including respiration, gas sensing...
به منظور ارزیابی قابلیت دادههای سنجندههای hrg ماهواره spot 5 و liss-iii ماهواره irs-p6 در تهیه نقشه و تفکیک محوطه های جنگلی گلازنی شده در زاگرس شمالی، بخشی از جنگلهای گلازنی شده شهرستان بانه انتخاب و مورد بررسی قرار گرفت. سطح محوطه های گلازنی شده (شان، کورپه، کور و خرت) در یک دوره تناوب 3 ساله با استفاده از دستگاه موقعیتیاب جهانی (gps) به عنوان واقعیت زمینی منطقه انتخاب گردید. پس از بررسی خط...
PURPOSE Tumors with oncogenic dependencies on the HER family of receptor tyrosine kinases (RTKs) often respond well to targeted inhibition. Our previous work suggested that many cell lines derived from squamous cell carcinomas of the head and neck (SCCHNs) depend on autocrine signaling driven by HER2/3 dimerization and high-level co-expression of HRG. Additionally, results from a Phase I trial ...
Streptococcus pyogenes is a significant bacterial pathogen in humans. In this study, histidine-rich glycoprotein (HRG), an abundant plasma protein, was found to kill S pyogenes. Furthermore, S pyogenes grew more efficiently in HRG-deficient plasma, and clots formed in this plasma were significantly less effective at bacterial entrapment and killing. HRG-deficient mice were strikingly more susce...
Histidine-rich glycoprotein (HRG) is synthesized by liver and is present at relatively high concentration in the plasma of vertebrates. We have previously described the association of a HRG-like molecule to purified rabbit skeletal muscle AMP deaminase (AMPD). We also provided the first evidence for the presence of a HRG-like protein in human skeletal muscle where a positive correlation between...
The exposure of cells to growth factors has been shown to induce cytoskeleton reorganization, leading to stimulation of cell motility and invasion. Heregulin beta1 (HRG), a combinatorial ligand for human epidermal growth factor receptor 3 and human epidermal growth factor receptor 4 receptors, is a regulatory secretory polypeptide with a distinctive function in promoting motility and invasivene...
Heregulin (HRG) belongs to a family of polypeptide growth factors that bind to receptor tyrosine kinases ErbB3 and ErbB4. HRG binding induces ErbB3 and ErbB4 heterodimerization with ErbB2, activating downstream signal transduction. Vascular endothelial growth factor (VEGF) is a primary regulator of physiological angiogenesis and is a major mediator of pathological angiogenesis, such as tumor-as...
Heparin binding to rabbit histidine-rich glycoprotein (HRG) was studied in a purified system, allowing for determination of a heparin dissociation constant of approximately 5.5 X 10(-8) M for the interaction with HRG at pH 7.0. The strong interaction between heparin and HRG was demonstrated to be competitive with the binding of both antithrombin and thrombin to the heparin chain. HRG was furthe...
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