نتایج جستجو برای: spion

تعداد نتایج: 289  

2013
Jin Joo Hue Hu-Jang Lee Sangyong Jon Sang Yoon Nam Young Won Yun Jong-Soo Kim Beom Jun Lee

Free Cy5.5 dye and Cy5.5-labeled thermally cross-linked superparamagnetic iron oxide nanoparticles (TCL-SPION) have been routinely used for in vivo optical imaging. However, there is little information about the distribution and accumulation of free Cy5.5 dye and Cy5.5-labeled TCL-SPION in the tissues of mice. Free Cy5.5 dye (0.1 mg/kg body weight) and Cy5.5-labeled TCL-SPION (15 mg/kg body wei...

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2016
Ioannis Angelopoulos Paul Southern Quentin A. Pankhurst Richard M. Day

Superparamagnetic iron oxide nanoparticles (SPION) are used for an increasing range of biomedical applications, from imaging to mechanical actuation of cells and tissue. The aim of this study was to investigate the loading of smooth muscle cells (SMC) with SPION and to explore what effect this has on the phenotype of the cells. Adherent human SMC were loaded with ∼17 pg of unconjugated, negativ...

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Journal: :Journal of Nanobiotechnology 2006
Fadee G Mondalek Yuan Yuan Zhang Bradley Kropp Richard D Kopke Xianxi Ge Ronald L Jackson Kenneth J Dormer

BACKGROUND Sensorineural hearing loss, a subset of all clinical hearing loss, may be correctable through the use of gene therapy. We are testing a delivery system of therapeutics through a 3 cell-layer round window membrane model (RWM model) that may provide an entry of drugs or genes to the inner ear. We designed an in vitro RWM model similar to the RWM (will be referred to throughout the pape...

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Journal: :Molecules 2015
Annkathrin Hornung Marina Poettler Ralf P Friedrich Jan Zaloga Harald Unterweger Stefan Lyer Johannes Nowak Stefan Odenbach Christoph Alexiou Christina Janko

Major problems of cancer treatment using systemic chemotherapy are severe side effects. Magnetic drug targeting (MDT) employing superparamagnetic iron oxide nanoparticles (SPION) loaded with chemotherapeutic agents may overcome this dilemma by increasing drug accumulation in the tumor and reducing toxic side effects in the healthy tissue. For translation of nanomedicine from bench to bedside, n...

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2017
Marina Pöttler Anna Fliedner Eveline Schreiber Christina Janko Ralf Philipp Friedrich Christopher Bohr Michael Döllinger Christoph Alexiou Stephan Dürr

PURPOSE The voice is the most important instrument of communication. Tissue defects in the vocal fold (VF) area lead to serious reduction in quality of life, but thus far, no satisfactory VF implant exists. Therefore, we aim to establish a functional VF implant in a rabbit model by magnetic tissue engineering (MTE) using superparamagnetic iron oxide nanoparticles (SPION). Hence, iron quantifica...

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2012
Paolo Bigini Valentina Diana Sara Barbera Elena Fumagalli Edoardo Micotti Leopoldo Sitia Alessandra Paladini Cinzia Bisighini Laura De Grada Laura Coloca Laura Colombo Pina Manca Patrizia Bossolasco Francesca Malvestiti Fabio Fiordaliso Gianluigi Forloni Massimo Morbidelli Mario Salmona Daniela Giardino Tiziana Mennini Davide Moscatelli Vincenzo Silani Lidia Cova

Stem Cell (SC) therapy is one of the most promising approaches for the treatment of Amyotrophic Lateral Sclerosis (ALS). Here we employed Super Paramagnetic Iron Oxide nanoparticles (SPIOn) and Hoechst 33258 to track human Amniotic Fluid Cells (hAFCs) after transplantation in the lateral ventricles of wobbler (a murine model of ALS) and healthy mice. By in vitro, in vivo and ex vivo approaches ...

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2014
Azza Gramoun Lindsey A Crowe Lionel Maurizi Wolfgang Wirth Frank Tobalem Kerstin Grosdemange Geraldine Coullerez Felix Eckstein Marije I Koenders Wim B Van den Berg Heinrich Hofmann Jean-Paul Vallée

INTRODUCTION Rheumatoid arthritis (RA) is a chronic disease causing recurring inflammatory joint attacks. These attacks are characterized by macrophage infiltration contributing to joint destruction. Studies have shown that RA treatment efficacy is correlated to synovial macrophage number. The aim of this study was to experimentally validate the use of in vivo superparamagnetic iron oxide nanop...

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2014
Yujin Sun Hoe Suk Kim Jinho Park Mulan Li Lianji Tian YoonSeok Choi Byung Ihn Choi Sangyong Jon Woo Kyung Moon

The identification of breast tumor initiating cells (BTICs) is important for the diagnosis and therapy of breast cancers. This study was undertaken to evaluate whether the extra domain-B of fibronectin (EDB-FN) could be used as a new biomarker for BTICs and whether EDB-FN targeting superparamagnetic iron oxide nanoparticles (SPIONs) could be used as a magnetic resonance imaging (MRI) contrast a...

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Journal: :iranian biomedical journal 0
سلیم البخاتی salim albukhaty حسین نادری منش hossein naderi-manesh تقی طریحی taki tiraihi

background: the magnetic nanoparticle-based transfection method is a relatively new technique for delivery of functional genes to target tissues. we aimed to evaluate the transfection efficiency of rat neural stem cell (nsc) using poly-l-lysine hydrobromide (pll)-coated super paramagnetic iron oxide nanoparticles (spion). methods: the spion was prepared and coated with pll as transfection agent...

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2014
Bashiru Kayode Sodipo Azlan Abdul Aziz

We report a sonochemical method of functionalizing superparamagnetic iron oxide nanoparticles (SPION) with (3-aminopropyl)triethoxysilane (APTES). Mechanical stirring, localized hot spots and other unique conditions generated by an acoustic cavitation (sonochemical) process were found to induce a rapid silanization reaction between SPION and APTES. FTIR, XPS and XRD measurements were used to de...

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