An efficient and environmentally friendly sample preparation method based on the application of hydrophobic 1-Hexylpyridinium hexafluorophosphate [Hpy][PF(6)] ionic liquid (IL) as a microextraction solvent was proposed to preconcentrate terazosin. The performance of the microextraction method was improved by introducing a common ion of pyridinium IL into the sample solution. Due to the presence...

AIM To investigate the autofluorescence spectroscopic differences in normal and adenomatous colonic tissues and to determine the optimal excitation wavelengths for subsequent study and clinical application. METHODS Normal and adenomatous colonic tissues were obtained from patients during surgery. A FL/FS920 combined TCSPC spectrofluorimeter and a lifetime spectrometer system were used for flu...

Thirty chalcone derivatives were synthesized via a base catalyzed Claisen Schmidt condensation and evaluated for their anti-methicillin-resistant Staphylococcus aureus (MRSA) activity alone and in combination with norfloxacin. Among these, 5 derivatives namely trans-3-(1H-indol-3-yl)-1-(40benzyloxyphenyl)-2-propen-1-one (2), 1-(400-biphenyl)-3-(3040-dihydroxyphenyl)-2-propen-1-one (11), 1(400-h...

BACKGROUND AND OBJECTIVES A number of studies have shown that nicotine has an antidepressant-like effect. The prevalence of smoking is much higher in people suffering from depression. In addition, the administration of nicotine from transdermal nicotine patch can exert antidepressant activity in nonsmokers and the continuous infusion of nicotine to rats attenuates learned helplessness, a putati...

A real-time fluorescence assay system using a series of 9-N-(alkylamino)acridine derivatives (methyl, ethyl, n-propyl, n-butyl, n-pentyl, and benzyl) that are N-dealkylated to 9-aminoacridine (9AA) is described. The product, 9AA, is approximately 27-fold more fluorescent than the substrates using excitation and emission wavelengths of 405 and 455 nm, respectively. Tests using expressed CYP1A1, ...

Objectives: Serum tPSA lacks specificity. The DD3 gene is highly specific for prostate cancer and is detectable in prostate cancer cells shedded into urine after rectal palpation. A newly developed nucleic acid sequence based amplification assay (uPM3) for detecting DD3 RNA in urine samples was evaluated prospectively in patients referred for prostate cancer detection. Methods: The uPM3 assay s...

Fluorescent probes can be used to monitor changes in the structure of cell membranes (Radda & Vanderlooi, 1972). In the present study 8-anilinonaphthalene-lsulphonic acid, 12-(9-anthroyI)stearate and N-phenylnaphthylamine have been mixed with fragments of plasma membrane prepared from rat adipocytes (Rodbell, 1967 ; Czech & Lynn, 1973). The intensity and polarization of the resulting fluorescen...

Abstract In oil production, a reservoir flooding system is often used. This necessary to compensate for production in the and maintain pressure. But water cutting of wells constantly increasing, that makes exploitation less profitable, future this leads shutdown wells. The source supply well not always clear, presence flooded below overlying reservoirs from which was previously carried out, pos...

BACKGROUND AND THE PURPOSE OF THE STUDY Ofloxacin is a quinolone synthetic antibiotic, which acts against resistant mutants of bacteria by inhibiting DNA gyrase. This antibacterial agent is widely used in the treatment of respiratory tract, urinary tract and tissue-based infections, which are caused by Gram-positive and Gram-negative bacteria. In this work, an efficient modified ionic liquid co...