The variegated picture of tuiberculous infection, both spontaneous in man and experimentally induced in animals, has puzzled students and led to most complicated explanations. Most of the earlier experimental studies were handicapped by the lack of two fundamentals which now appear so essential to a solution. One of these was the primary lack of information on the tubercle bacillus and its viru...

A large mucosal immune system controlled by unique, organ-specific regulations operates alongside and separate from the peripheral or systemic immune system. This local immune system is seen as a major interface between the innate and the specific immune system. We have been interested in the immunopathogenesis of a chronic inflammatory bowel disease (IBD) developing in CD4+ T cell-transplanted...