aortic aneurysm is a rare but potentially lethal complication during pregnancy. in this article we described a 30-year-old woman with a large size descending aorta aneurysm (11 cm in length and 5.6 cm in its greatest diameter), who had two term uncomplicated pregnancies. the patient received prophylactic ß-blocker drug during her second pregnancy. both pregnancies were terminated by caesarean s...

mebudipine is a new dihydropyridine calcium channel blocker, synthesized in our laboratory, for treatment of hypertension. it has shown a better efficacy than other drugs in this group. for assessing the risks of this drug, certain safety tests in the preclinical stage have been performed. in this study mutagenic effect of mebudipine was evaluated using ames assay that could assess the mutageni...

The magnetoelastic (ME) biosensors are used to detect pathogen in fresh juice or milk by solenoid coil, and also developed for real-time, direct pathogen detection on food surfaces by surface-scanning coil. This paper presents blocking effect of different reagents on non-specific binding for detecting Salmonella typhimurium in apple juice using phage-based magnetoelastic biosensors. Three diffe...

In the present study, we investigated the effects of histamine and its specific H(1), H(2) and H(3) receptor blockers in cerebellar granular cell culture derived from rat pups. Histamine was applied at 10(-9),10(-8), 10(-7),10(-6), and 10(-5) M for 16 h into the cultures and the highest dose was found to be the most toxic one. Pheniramine (H(1) receptor blocker), ranitidine (H(2) receptor block...

Introduction: Neurons in layer II and III of the somatosensory cortex in rats show high frequency (33 ± 13 Hz) of miniature excitatory postsynaptic currents (mEPSCs) that their rates and amplitudes are independent of sodium channels. There are some changes in these currents in neurodegenerative and psychological disorders. Regarding to well known roles of the neuromodulatory brain systems in...

BACKGROUND Efforts to improve the quality of care for patients with cardiovascular disease frequently target the decrease of physician-level performance variability. We assessed how variability in providing β-blockers to ambulatory postmyocardial infarction (MI) patients was influenced by physician and patient level characteristics. METHODS AND RESULTS β-Blocker prescription and patient chara...

INTRODUCTION Increasing evidence suggests that beta-blocker use might be associated with reduced mortality in prostate cancer patients. To provide a quantitative assessment of this association, we pooled data available to examine the association between beta-blocker use and mortality of prostate cancer. METHODS We identified studies by a literature search of MEDLINE (from 1 January 1966) and ...

OBJECTIVE To determine if the addition of preventive drug treatment (β blocker), brief behavioural migraine management, or their combination improves the outcome of optimised acute treatment in the management of frequent migraine. DESIGN Randomised placebo controlled trial over 16 months from July 2001 to November 2005. SETTING Two outpatient sites in Ohio, USA. PARTICIPANTS 232 adults (m...

The aims of this study were to assess the risk of tuberculosis (TB) and the status of latent tuberculosis infection (LTBI) in Korean patients with inflammatory bowel disease (IBD) receiving tumor necrosis factor (TNF)-α blockers. We reviewed medical records of 525 Korean IBD patients (365 TNF-α blocker naïve and 160 TNF-α blocker exposed) between January 2001 and December 2013. The crude incide...