Mutations in SPARTAN are associated with early onset hepatocellular carcinoma and progeroid features. A regulatory function of Spartan has been implicated in DNA damage tolerance pathways such as translesion synthesis, but the exact function of the protein remained unclear. Here, we reveal the role of human Spartan in facilitating replication of DNA-protein crosslink-containing DNA. We found th...

The Athenian recovery of Theseus’ bones from Scyros is known through a number of literary accounts spanning several centuries. The tradition dates the recovery to the early fifth century and connects it to the Athenian statesman Cimon. Modern reconstructions tend to rely on the combination of different (and possibly conflicting) sources. An analysis of the evidence, however, shows that the stor...

In book 1 Thucydides’ Corinthians attribute Athenian military success in the Archidamian war to an inherent national character. They empahsize the characteristics of agility, speed, and common-good seeking. Thucydides’ readers come to realize that the Athenian “democratic advantage” stemmed from a superior capacity to organize useful knowledge. Knowledge management in military affairs can be le...

The Spartan®-3 families, consisting of Spartan-3, Spartan-3E, and Extended Spartan-3A devices, support an exceptionally robust and flexible I/O feature set, such that the signaling requirements of most applications can easily be met. It is possible to program User I/O pins of these families to handle many different single-ended signal standards. The standard single-ended signaling voltage level...