Intra-cerebral hemorrhage (ICH) is a particularly severe type of stroke accounting for 10–15 % of all strokes and is associated with a mortality rate of 30–50%. Neuroinflammation contributes to ICH-induced secondary brain injury and understanding the mechanisms causing neuroinflammation can be helpful to find new treatments of ICH. Recent studies demonstrated that toll like receptor...

Neuroblastoma is one of the most common solid tumors and accounts for ∼ 15% of all the cancer related deaths in the children. Despite the standard therapy for advanced disease including chemotherapy, surgery, and radiation, the mortality rate remains high for these patients. Hence, novel therapeutic agents are desperately needed. Here we examined the anticancer activity of a novel plant-derived...

Gulf War Illness (GWI) is a chronic multi-symptom disorder that affected almost one-third of the deployed veterans during first Persian (1990-91). Symptoms include gastrointestinal disturbances, fatigue, cognitive deficiencies, and neuroinflammation. Our group has recently shown series different therapeutic strategies span oral butyrate, anti-viral drug Ribavirin, TLR4 antagonist Sparstolonin B...

[This corrects the article DOI: 10.1371/journal.pone.0096343.].