Submit Manuscript | http://medcraveonline.com Abbreviations: SLN: Solid Lipid Nanoparticles; PQ-SLNs: PQLoaded Solid Lipid Nanoparticles; o/w: Oil-in-Water; SA: Stearic Acid; PVA: Polyvinyl Alcohol; EtOAc: Ethyl Acetate; w/o: Waterin-Oil; PDI: Poly Dispersity Index; DLS: Dynamic Light Scattering; FD: Freeze Drying; HEPES: N-2-Hydroxyethylpiperazine-N-2Ethanesulfonic Acid; NP: Nanoformulated Pri...

abstractvarious nanoparticles have been investigated as novel drug delivery systems, including solid lipid nanoparticles (slns). due to their rapid clearance from systemic circulation, nanoparticles do not provide sustained action in most cases. different strategies have been employed to overcome this problem. in this direction, the present study introduces erodible in-situ forming gel systems ...

Transdermal patches loaded with Solid Lipid Nanoparticles has been used as a suitable dosage to maintain the blood glucose level in diabetic patients. Repaglinide was taken as model antidiabetic drug get incorporated in Solid lipid Nanoparticles (SLNs) by a hot homogenization method using cephalin and lecithin as lipids and Tween 80 as stabilizer. The prepared nanoparticles evaluated for partic...

Solid lipid nanoparticles (SLN) is a potential alternative method for drug delivery due to its good stability, low toxicity, can be modified and controlled in release, as well produced on large scale. The SLNs are composed of solid lipids stabilized by emulsifiers. used SLN physiological that easily tolerated the body. These characteristics make system increase efficiency an antibiotics prepara...

Sorafenib solid lipid nanoparticles (S-SLN) were prepared by emulsion evaporation-solidification at low temperature. Morphology was examined by transmission electron microscope. Particle size and zeta potential were determined by laser granularity equipment. Encapsulation efficiency (EE) was detected by Sephadex gel chromatography and high-performance liquid chromatography (HPLC). The in vitro ...

The aim of this work was to develop and evaluate solid lipid nanoparticles (SLN) containing all-transretinoic acid (ATRA) for topical delivery. SLN composed of coconut oil and curdlan improved the suspension instability of ATRA in aqueous solution. The photodegradation of ATRA by light was reduced by incorporation in SLN. The loading efficiency of ATRA in SLN was higher than 95% (w/w). The amou...

Enhancing oral bioavailability of hydrophilic drugs by encapsulation in lipid-based nanocarriers, including Solid Lipid Nanoparticles (SLN), has been well documented. In this work, high molecular weight heparin was “insolubilized” an “ion-paring” approach, forming Chitosan/Heparin Polyelectrolyte Complexes (PEC) to promote its SLN. Hybrid PEC-SLN, heparin-loaded SLN (H-SLN) as naked PEC were pr...

BACKGROUND AND THE PURPOSE OF THE STUDY Domperidone (DOM) is a dopamine- receptor (D(2)) antagonist, widely used in the treatment of motion-sickness. The pharmacokinetic parameters of DOM make it a suitable candidate for development of Solid Lipid Nanoparticle (SLN) and Nanostructured Lipide Carrier (NLC). The purpose of the present investigation was to prepare and evaluate DOM loaded solid lip...

Raloxifene hydrochloride (RL-HCL) is an orally selective estrogen receptor modulator (SERM) with poor bioavailability of nearly 2% due to its poor aqueous solubility and extensive first pass metabolism. In order to improve the oral bioavailability of raloxifene, raloxifene loaded solid lipid nanoparticles (SLN) have been developed using Compritol 888 ATO as lipid carrier and Pluronic F68 as sur...

AbstractVarious nanoparticles have been investigated as novel drug delivery systems, including solid lipid nanoparticles (SLNs). Due to their rapid clearance from systemic circulation, nanoparticles do not provide sustained action in most cases. Different strategies have been employed to overcome this problem. In this direction, the present study introduces erodible in-situ forming gel systems ...