Members of the Tolloid family of metalloproteinases liberate BMPs from inhibitory complexes to regulate BMP gradient formation during embryonic dorsal-ventral axis patterning. Here, we determine mechanistically how Tolloid activity is regulated by its non-catalytic CUB domains in the Drosophila embryo. We show that Tolloid, via its N-terminal CUB domains, interacts with Collagen IV, which enhan...

Concentration gradients of morphogens are known to be instrumental in cell signaling and tissue patterning. Of interest here is how the presence of a competitor of BMP ligands affects cell signaling. The effects of Sog on the binding of Dpp with cell receptors are analyzed for dorsal-ventral morphogen gradient formation in vertebrate and Drosophila embryos. This prototype system includes diffus...

Reconfiguration of the respiratory network at the onset of locust flight. J. Neurophysiol. 80: 3137-3147, 1998. The respiratory interneurons 377, 378, 379 and 576 were identified within the suboesophageal ganglion (SOG) of the locust. Intracellular stimulation of these neurons excited the auxillary muscle 59 (M59), a muscle that is involved in the control of thoracic pumping in the locust. Like...

In flies, the maxillary palp possesses olfactory sensilla housing olfactory receptor neurons (ORNs), which project to the primary olfactory center, the antennal lobes (ALs). The labellum possesses gustatory sensilla housing gustatory receptor neurons (GRNs), which project to the primary gustatory center, the subesophageal ganglion (SOG). Using an anterograde staining method, we investigated the...

Dorsal cell fate in Drosophila embryos is specified by an activity gradient of Decapentaplegic (Dpp), a homologue of bone morphogenetic proteins (Bmps) 2/4. Previous genetic and biochemical studies have revealed that the Sog, Tsg and Tld proteins modify Dpp activity at the post-transcriptional level. The predominant view is that Sog and Tsg form a strong ternary complex with Dpp that prevents i...

Drought is a significant climatic disturbance in grasslands, yet the impact drought caused by global warming has on grassland phenology is still unclear. Our research investigates the long-term variability of grassland phenology in relation to drought in the Canadian prairies from 1982 to 2014. Based on the start of growing season (SOG) and the end of growing season (EOG) derived from Global In...

The authors demonstrate “smart-cut”-type layer transfer of single-crystal silicon carbide (SiC) by using spinon-glass (SoG) as an adhesion layer. Using SoG as an adhesion layer is desirable because it can planarize the surface, facilitate an initial low temperature bond, and withstand the thermal stresses at high temperature where layer splitting occurs (800–900 °C). With SoG, the bonding of wa...

We have studied the effect of phospholipase C from Bacillus cereus and Clostridium perfringens (alpha-toxin) on giant stearoyl-oleoyl phosphatidylcholine (SOPC) vesicles. Enzyme activity leads to a binary mixture of SOPC and the diacylglycerol SOG, which phase separates into a SOPC-rich bilayer phase and a SOG-rich isotropic bulk-like domain embedded within the membrane, as seen directly by pha...

The Symbolic Observation Graph (SOG) associated with a labelled transition system and a subset of its labels is an efficient BDDbased abstraction representing the behavior of a system. The goal of this paper is to compose SOGs such that the resulting SOG is still small but represents the behavior of the composed business process in an appropriate way. In particular, we would like to deduce the ...