Following injury, primary sensory neurons undergo changes that drive central sensitization and contribute to the maintenance of persistent hypersensitivity. NR2B expression in the dorsal root ganglia (DRG) has not been previously examined in neuropathic pain models. Here, we investigated if changes in NR2B expression within the DRG are associated with hypersensitivities that result from periphe...

BACKGROUND The spared nerve injury (SNI) model of neuropathic pain produces robust and reproducible behavioral mechanical hypersensitivity. Although this rodent model of neuropathic pain has been well established and widely used, peripheral mechanisms underlying this phenotype remain incompletely understood. Here we investigated the role of cutaneous sensory fibers in the maintenance of mechani...

Syntactic noun incorporation (SNI) in Danish is a phenomenon that has reeexes in phonology, syntax, semantics and pragmatics. In contrast with morphological noun incorporation, which involves compounding of an N stem and a V stem to yield a larger, derived V stem (Mithun, 1984, 847), SNI does not involve any overt word order perturbation or overt morphology, but is rather expressed prosodically...

BACKGROUND Recently we showed that unilateral peripheral neuropathic lesions impacted differentially on rat's emotional/cognitive behavior depending on its left/right location; importantly, this observation recapitulates clinical reports. The prefrontal cortex (PFC), a brain region morphofunctionally affected in chronic pain conditions, is involved in the modulation of both emotion and executiv...

BACKGROUND Recently, fatty acids have been shown to modulate sensory function in animal models of neuropathic pain. In this study, the antinociceptive effect of 2-hydroxyoleic acid (2-OHOA) was assessed following spared nerve injury (SNI) with reflex and cerebrally mediated behavioural responses. METHODS Initial antinociceptive behavioural screening of daily administration of 2-OHOA (400 mg/k...

We study two specific features of onsite breathers in Nonlinear Schrödinger systems on d-dimensional cubic lattices with arbitrary power nonlinearity (i.e., arbitrary nonlinear exponent, n): their wavefunctions and energies close to the anti-continuum limit – small hopping limit – and their excitation thresholds. Exact results are systematically compared to the predictions of the so-called expo...

Syntactic noun incorporation (SNI) in Danish is a phenomenon that has reflexes in phonology, syntax, semantics and pragmatics. In contrast with morphological noun incorporation, which involves compounding of an N stem and a V stem to yield a larger, derived V stem (Mithun, 1984, 847), SNI does not involve any overt word order perturbation or overt morphology, but is rather expressed prosodicall...

Peripheral nerve injury alters the expression of hundreds of proteins in dorsal root ganglia (DRG). Targeting some of these proteins has led to successful treatments for acute pain, but not for sustained post-operative neuropathic pain. The latter may require targeting multiple proteins. Since a single microRNA (miR) can affect the expression of multiple proteins, here, we describe an approach ...

Purpose: A previously described Doppler parameter, the sonographic NASCET index (SNI), was derived to be more directly analogous to the North American Symptomatic Carotid Endarterectomy Trial (NASCET) methodology for assessing carotid artery stenosis. However, this index does not account for complex changes affecting the Doppler waveform. We propose a revised SNI (rSNI) in an effort to improve ...

Standardized laboratory testing of wood and wood-based products against subterranean termites in Indonesia (SNI 01.7207-2006) (SNI) has no requirement for the inclusion of a comparative reference species of wood (reference control). This is considered a weakness of the Indonesian standard. Consequently, a study was undertaken to identify a suitable Indonesian species of community wood that coul...