In the title complex, [Sn(C(2)H(2)ClO(2))(2)(C(7)H(6)F)(2)], the Sn(IV) atom is located on a twofold rotation axis and forms a strongly distorted trans-octa-hedral geometry. The equatorial plane is defined by two chelating chloro-acetate ligands with asymmetrical Sn-O bond lengths, while the axial positions are occupied by the C atoms of two 2-fluoro-benzyl groups. In the crystal, infinite chai...

Synthesis of 1-sn-phosphatidyl-3'-sn-glycero-1'-sulfate (phosphatidylglycero-1-sulfate) was achieved by monosulfation of 1-sn-phosphatidyl-3'-sn-glycerol (diphytanyl ether analog) with an equimolar amount of SO(3)-pyridine complex at room temperature; with excess sulfation reagent at 60 degrees C, the 1',2'-disulfate ester was obtained. The phosphatidyl-glycero-2-sulfate isomer was synthesized ...

A complex between d(GGGAAAAACGG).d(CCGTTTTTCCC) and the minor groove binding drug SN-6999 has been studied by 1H nuclear magnetic resonance spectroscopy. The drug is found to bind in the d(A)5 tract, but with interactions extending one residue in the 3'-direction along each strand. Doubling of resonances in the complex indicates slow to intermediate exchange between two binding modes. An orient...

Zeeman C1 NQR spectroscopy has been applied to determine the magnitude and orientation of the E F G tensors at the chlorine sites in a single crystal of (CH 3 NH 3 ) 2 [ (C 2 H 5 )SnCl 5 ] at 293 K. The assignment of the N Q R frequencies v ;(Cl), the corresponding quadrupole coupling constants e Q f P ^ h ^ 1 , and the asymmetry parameters f/,(C 1) to certain Cl' atoms is discussed. The most p...

Representation theory is a way of studying complex mathematical structures such as groups and algebras by mapping them to linear actions on vector spaces. Recently, Deligne proposed a new way to study the representation theory of finite groups by generalizing the collection of representations of a sequence of groups indexed by positive integer rank to an arbitrary complex rank, creating an abel...

Mitochondrial defects within substantia nigra (SN) neurons are implicated in the pathogenesis of Parkinson's disease. SN neurons show increased mitochondrial defects, mitochondrial DNA deletion levels, and susceptibility to such dysfunction, although the role of mitochondria in neuronal degeneration remains uncertain. In this study, we addressed this important question by exploring changes with...

The reaction of the lithium tris(2-pyridyl)stannate [LiSn(2-py)3] (py6OtBu = C5H3N-6-OtBu), 1, with the element(II) amides E{N(SiMe3)2}2 (E = Sn, Pb) afforded complexes [LiE{Sn(2-py)3}3] for E = Sn (2) and E = Pb (3), which reveal three Sn–E bonds each. Compounds 2 and 3 have been characterized by solution NMR spectroscopy and X-ray crystallographic studies. Large 1J(119Sn–119/117Sn) as well as...

The STERILE NODES (SN) locus in pea (Pisum sativum) was one of the first photoperiod response genes to be described and provided early evidence for the genetic control of long-distance signaling in flowering-time regulation. Lines homozygous for recessive sn mutations are early flowering and photoperiod insensitive, with an increased ability to promote flowering across a graft union in short-da...

In the dinuclear title complex, [Sn(2)(CH(3))(4)(C(7)H(3)F(2)O(2))(4)], the Sn(IV) atom is chelated by two 3,5-difluoro-benzoate (dfb) anions and coordinated by two methyl groups while an O atom from the adjacent dfb anion bridges the Sb atom with a longer Sb-O bond distance of 2.793 (4) Å. The complex mol-ecule has 2 symmetry and the Sn(IV) atom is in a distorted penta-gonal-bipyramidal coordi...

Parkinson's disease is a neurodegenerative disorder characterized by the preferential loss of midbrain dopaminergic neurons in the substantia nigra (SN). One of the earliest detectable biochemical alterations that occurs in the Parkinsonian brain is a marked reduction in SN levels of total glutathione (glutathione plus glutathione disulfide), occurring before losses in mitochondrial complex I (...