The purpose of this study was to prepare a dutasteride-loaded solid-supersaturatable self-microemulsifying drug delivery system (SMEDDS) using hydrophilic additives with high oral bioavailability, and to determine if there was a correlation between the in vitro dissolution data and the in vivo pharmacokinetic parameters of this delivery system in rats. A dutasteride-loaded solid-supersaturatabl...

The oral delivery of lipophilic drugs presents a major challenge because of the low aqueous solubility of such compounds. Selfmicroemulsifying drug delivery systems (SMEDDSs) have gained exposure for their ability to increase solubility and bioavailability of poorly soluble drugs. SMEDDS, which are isotropic mixtures of oils, surfactants, solvents and co-solvents/surfactants, can be used for th...

Objective: To prepare and evaluate lipid based drug delivery systems of Tacrolimus. Methods: Lipid based solid dispersion (SD) and self microemulsifying drug delivery systems (SMEDDS) of Tacrolimus are prepared and evaluated. Firstly, solid dispersions, liquid and solid self microemulsifying drug delivery systems of Tacrolimus were prepared. Prepared formulations were evaluated by dissolution t...

A colon-specific capsule with alginate beads containing a self-microemulsifying drug delivery system (SMEDDS) was developed and evaluated. The SMEDDS technique was used to improve the solubility of curcumin (Cur). After encapsulating the Cur-loaded SMEDDS, the alginate beads were placed inside an impermeable capsule body. A konjac glucomannan/lactose/hydroxypropyl methylcellulose (KG/Lac/ HPMC)...

The supersaturatable self-microemulsifying drug delivery system (S-SMEDDS) represents a new thermodynamically stable formulation approach wherein it is designed to contain a reduced amount of surfactant and a water-soluble polymer (precipitation inhibitor or supersaturated promoter) to prevent precipitation of the drug by generating and maintaining a supersaturated state in-vivo. The supersatur...

− Fenofibrate has been used for many years to lower cholesterol levels and its pharmacokinetic profile is well understood. However, due to its low solubility in water, it has low bioavailability after oral administration. In order to improve the dissolution rate, fenofibrate was formulated into a self-microemulsifying drug delivery systems (SMEDDS). We used pseudo-ternary phase diagrams to eval...

the supersaturatable self-microemulsifying drug delivery system (s-smedds) represents a new thermodynamically stable formulation approach wherein it is designed to contain a reduced amount of surfactant and a water-soluble polymer (precipitation inhibitor or supersaturated promoter) to prevent precipitation of the drug by generating and maintaining a supersaturated state in-vivo. the supersatur...

In this study, we developed and optimized a self-microemulsifying drug delivery system (SMEDDS) formulation for improving the dissolution and oral absorption of atorvastatin calcium (ATV), a poorly water-soluble drug. Solubility and emulsification tests were performed to select a suitable combination of oil, surfactant, and cosurfactant. A D-optimal mixture design was used to optimize the conce...

The present work was aimed at formulating a SMEDDS (Self-microemulsifying drug delivery system) for oral drug delivery system containing flutamide. The solubility of flutamide was determined in various vehicles. Pseudo ternary phase diagram was constructed to identify the micro emulsification existence area. SMEDDS formulations were tested for microemulsifying properties, and the resultant form...

To enhance the dissolution and oral bioavailability of poorly water-soluble biphenyl dimethyl dicarboxylate (BDD), supersaturatable self-microemulsifying drug delivery system (S-SMEDDS) was developed by adding a polymer PVP to prevent precipitation maintain supersaturate state in vivo. Ternary phase diagrams were drawn evaluate microemulsification domain. The formulations characterized testing ...