OBJECTIVES An increasing prevalence since 2010 of Serratia marcescens harbouring the Ambler class A carbapenemase SME prompted us to further characterize these isolates. METHODS Isolates harbouring bla(SME) were identified by PCR and sequencing. Phenotypic analysis for carbapenemase activity was carried out by a modified Hodge test and a modified Carba NP test. Antimicrobial susceptibilities ...

Secure multi-execution (SME) is a promising black-box technique for enforcing information flow properties. Unlike traditional static or dynamic language-based techniques, SME satisfies noninterference (soundness) by construction and is also precise. SME executes a given program twice. In one execution, called the high run, the program receives all inputs, but the program’s public outputs are su...

Small nuclear ribonucleoproteins are essential splicing factors. We previously identified the spliceosomal protein E (SmE) as a downstream effector of E2F1 in p53-deficient human carcinoma cells. Here, we investigated the biological relevance of SmE in determining the fate of cancer and non-tumourigenic cells. Adenovirus-mediated expression of SmE selectively reduces growth of cancerous cells d...

The present study investigated the photoprotective properties of the ethyl acetate fraction of Sargassum muticum (SME) against ultraviolet B (UVB)‑induced skin damage and photoaging in a mouse model. HR‑1 strain hairless male mice were divided into three groups: An untreated control group, a UVB‑irradiated vehicle group and a UVB‑irradiated SME group. The UVB‑irradiated mice in the SME group we...

Secure multi-execution (SME) is a dynamic technique to ensure secure information ow. In a nutshell, SME enforces security by running one execution of the program per security level, and by reinterpreting input/output operations w.r.t. their associated security level. SME is sound, in the sense that the execution of a program under SME is non-interfering, and precise, in the sense that for progr...

The work presented in this paper is related to the area of Situational Method Engineering (SME), which focuses on project-specific method construction. We propose a generic process model supporting the integration of different existing SME approaches. This model shall help the method engineer either selecting one SME approach or combining several approaches that best fit the situation of the me...

This paper presents an approach to the identification of requirements for the implementation of e-business solutions in small and medium sized enterprises (SME). The approach is based on the so-called reference models whose main purpose is to guide the process of deriving the detailed requirements for business processes and information systems support, regarding e-business activities. Firstly, ...

Growth is a problematic issue for SME. It consumes resources and, since resources are structurally limited in SME, development strategies often generate real dilemmas (Martinet, 1981). Leverage strategies are frequently applied in an attempt to get around the problem. Nevertheless, such approaches to growth upset the proxemic management processes characteristic of SME (Torres, 2000), notably in...

The aim of this study was to examine the effect of standardized extract of Salvia miltiorrhiza (SME) on gene and protein expression of non-alcoholic steatohepatitis (NASH)-related factors in activated human hepatic stellate cells (HSC), and in mice with steatohepatitis induced by a methionine-choline deficient (MCD) diet. Male C57BL/6J mice were placed on an MCD or control diet for 8 weeks and ...

The sensitive dependence on initial conditions (SDIC) associated with nonlinear models imposes limitations on the models’ predictive power. We draw attention to an additional limitation than has been under-appreciated, namely structural model error (SME). A model has SME if the model-dynamics differ from the dynamics in the target system. If a nonlinear model has only the slightest SME, then it...