We built a SEIR (susceptible, exposed, infected, recovered) model of smallpox transmission for New York, New York, USA, and Sydney, New South Wales, Australia, that accounted for age-specific population immunosuppression and residual vaccine immunity and conducted sensitivity analyses to estimate the effect these parameters might have on smallpox reemergence. At least 19% of New York's and 17% ...

Eradication of the smallpox virus through extensive global vaccination efforts has resulted in one of the most important breakthroughs in medical history, saving countless lives from the severe morbidity and mortality that is associated with this disease. Although smallpox is now extinct in nature, laboratory stocks of this virus still remain and the subject of smallpox vaccination has gained r...

The last case of natural smallpox was recorded in October, 1977. It took humanity almost 20 years to achieve that feat after the World Health Organization had approved the global smallpox eradication program. Vaccination against smallpox was abolished, and, during the past 40 years, the human population has managed to lose immunity not only to smallpox, but to other zoonotic orthopoxvirus infec...

Ross, P. J., Seaton, A., Foreman, H. M., and Morris Evans, W. H. (1974). Thorax, 29, 659-665. Pulmonary calcification following smallpox handler's lung. A follow-up study of six nurses who developed smallpox handler's lung during the 1962 South Wales smallpox epidemic and of the surviving smallpox patients is reported. The development of extensive punctate calcification in the chest radiographs...

Find the secret to improve the quality of life by reading this edward jenner and the history of smallpox and vaccination. This is a kind of book that you need now. Besides, it can be your favorite book to read after having this book. Do you ask why? Well, this is a book that has different characteristic with others. You may not need to know who the author is, how well-known the work is. As wise...

We present a stochastic model for the spread of smallpox after a small number of index cases are introduced into a susceptible population. The model describes a branching process for the spread of the infection and the effects of intervention measures. We discuss scenarios in which ring vaccination of direct contacts of infected persons is sufficient to contain an epidemic. Ring vaccination can...

This article is a response to Davenport, Schwarz, and Boulton's article, ‘The decline of adult smallpox in eighteenth-century London’. It introduces new data on the parish of St Mary Whitechapel which casts doubt on the pattern of the age incidence of smallpox found by Davenport et al. However, it is concluded that there was a decline in adult smallpox in London, accompanied by a concentration ...

The first record of smallpox in Japan was found in the Nihon Shoki, published in 735 (the 7th year of Tempyo). The incident was also described in Ishinho, the oldest medical book in Japan, issued by Yasuyori Tanba in 984 (the 2nd year of Eikan). Smallpox, called Hoso in Japanese, came to Japan in the same era as Buddhism. The disease was considered very dangerous. Even those who recovered could...

The threat of using variola virus in a bioterrorist attack urged different countries to renew the production of traditional vaccines and develop new generations of smallpox vaccines. Manufacturers try to combine smallpox vaccine past experience with technological advances in vaccine development to achieve protection similar to that of the traditional vaccines with a higher level of safety and f...

Besides killing many of those who were infected, an attack of smallpox left most of its survivors pockmarked, and it was realized in ancient times that pockmarked persons never caught smallpox again . By accident, it was found that persons who were infected with smallpox via a scratch on the skin suffered a much less severe form of the disease . Long ago, in places in which smallpox had become ...