نتایج جستجو برای: smads

تعداد نتایج: 965  

Journal: :Cell 2009
Jeffrey L. Wrana

Smad4 is an important mediator of signaling by TGFbeta family members that is presumed to be controlled by the phosphorylation status of its partners, the receptor-regulated R-Smads. In this issue, Dupont et al. (2009) now reveal that Smad4 itself is subject to cycles of ubiquitination and deubiquitination that regulate its interactions with the R-Smads.

2005
Seok Hee Park

Transforming Growth Factor (TGF)-β family, including TGF-β, bone morphorgenic protein (BMP), and activn, plays an important role in essential cellular functions such as proliferation, differentiation, apoptosis, tissue remodeling, angiognesis, immune responses, and cell adhesions. TGF-β predominantly transmits the signals through serine/ threonine receptor kinases and cytoplasmic proteins calle...

Journal: :Journal of cell science 2004
Francisco J Nicolás Karolien De Bosscher Bernhard Schmierer Caroline S Hill

Transforming growth factor beta (TGF-beta) signalling leads to phosphorylation and activation of receptor-regulated Smad2 and Smad3, which form complexes with Smad4 and accumulate in the nucleus. The Smads, however, do not seem to reside statically in the cytoplasm in the absence of signalling or in the nucleus upon TGF-beta stimulation, but have been suggested to shuttle continuously between t...

Journal: :Cell 2009
Ye-Guang Chen Xiao-Fan Wang

TGF-beta ligands induce phosphorylation of receptor-activated Smads at both the C-terminal tail and the linker region. Two papers from Massagué and colleagues (Alarcón et al., 2009; Gao et al., 2009) reveal a dual role for this linker phosphorylation, which is required for activation of Smads and for their degradation.

2015
Ying Si Soojin Kim Xiangqin Cui Lei Zheng Shin J. Oh Tina Anderson Mohammad AlSharabati Mohamed Kazamel Laura Volpicelli-Daley Marcas M. Bamman Shaohua Yu Peter H. King Hoon Ryu

We recently identified Smads1, 5 and 8 as muscle biomarkers in human ALS. In the ALS mouse, these markers are elevated and track disease progression. Smads are signal transducers and become activated upon receptor engagement of ligands from the TGF-β superfamily. Here, we sought to characterize ligands linked to activation of Smads in ALS muscle and their role as biomarkers of disease progressi...

Journal: :Arquivos Brasileiros De Oftalmologia 2021

ABSTRACT Purpose: The present study aimed to investigate the inhibitory effect of fluorofenidone against transforming growth factor β2-induced proliferation and epithelial-mesenchymal transition in human lens epithelial cell line FHL 124 its potential mechanism. Methods: We evaluated on vitro. After treatment with 0, 0.1, 0.2, 0.4, 0.6, 1.0 mg/mL fluorofenidone, was measured via MTT assay. Cell...

Journal: :Cold Spring Harbor Perspectives in Biology 2016

2012
Elizabeth M. Callery Chong Yon Park Xin Xu Haitao Zhu James C. Smith Gerald H. Thomsen

Transforming growth factor β superfamily members signal through Smad transcription factors. Bone morphogenetic proteins (BMPs) act via Smads 1, 5 and 8 and TGF-βs signal through Smads 2 and 3. The endocytic adaptor protein Eps15R, or 'epidermal growth factor (EGF) receptor pathway substrate 15-related protein' is a component of EGF signal transduction, mediating internalization of the EGF recep...

2002
Sylviane Dennler Marie-José Goumans Peter ten Dijke

Transforming growth factor beta1 (TGF1) is the prototypic member of a large family of structurally related pleiotropic-secreted cytokines that play a pivotal role in the control of differentiation, proliferation, and state of activation of many different cell types including immune cells. TGFfamily members have potent immunosuppressor activities in vitro and in vivo. These cytokines trigger the...

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