Melanoma affects more than a million people in the United States. Regardless of skin tone, anybody may get cancer. Poor bioavailability, adverse side effects, and drug resistance have hampered current state for treating cutaneous melanoma other malignancies. Medicinal chemists want to explore different possible novel drugs increase availability, diversity-oriented synthesis (DOS) strategy aimed...

Fourteen new withanolides, 1-14, named withalongolides A-N, respectively, were isolated from the aerial parts of Physalis longifolia together with eight known compounds (15-22). The structures of compounds 1-14 were elucidated through spectroscopic techniques and chemical methods. In addition, the structures of withanolides 1, 2, 3, and 6 were confirmed by X-ray crystallographic analysis. Using...

We report the synthesis, photochemical and photophysical properties and preliminary studies on biological effect of a new tritolylporphyrin dimer (T-D). Absorption and emission properties of T-D suggest its possible use in photodynamic therapy. T-D is capable of singlet oxygen production with 0.8 quantum yield. It also has a high photostability. The photodynamic properties of the dimer were exa...

This work analyzed the chemical compositions and evaluated antioxidant cytotoxic activities of essential oils (EO) Eugenia patrisii (Epat), stipitata (Esti), Myrcia splendens (Mspl), sylvatica (Msyl), Psidium guajava (Pgua), guineense (Pgui-1 Pgui-2) from Brazilian Amazon. Sesquiterpenoids were found in high concentrations E. M. splendens, which rich E-caryophyllene (32.0% 45.8%); sylvatica, di...

A harmine-derived beta-carboline, CM16, inhibits cancer cells growth through its effects on protein synthesis, as described in "A harmine-derived beta-carboline displays anti-cancer effects in vitro by targeting protein synthesis" (Carvalho et al., 2017)[1]. This data article provides accompanying data on CM16 cytostatic evaluation in cancer cells as well as data related to its effects on trans...

5-AminolevuHnate (ALA) photodynamic therapy (PDT) is being used clinically for the treatment of skin cancers. ALA is applied as a precursor of porphyrins serving as endogenous photosensitizers. Irradiation of HaCaT cells preincubated with 1 HIMALA for 24 h with red light of 570-750 nm at a dose of 4.5 .I/cm' leads to a 6-fold elevation of cellular c-Jun N-terminal kinase activity; phosphorylati...

Reverse phase protein arrays (RPPA) are an efficient, high-throughput, cost-effective method for the quantification of specific proteins in complex biological samples. The quality of RPPA data may be affected by various sources of error. One of these, spatial variation, is caused by uneven exposure of different parts of an RPPA slide to the reagents used in protein detection. We present a metho...