OBJECTIVE Between November 1994 and April 1995, more than 3300 students in 49 schools in two counties in New York were potentially exposed to five school bus drivers with tuberculosis. This investigation was carried out to determine the extent of transmission of Mycobacterium tuberculosis among students. METHODS Components of the epidemiologic investigation included tuberculin skin-test scree...

The tuberculin skin test currently used to diagnose infection with Mycobacterium tuberculosis has poor diagnostic value, especially in geographic areas where the prevalence of tuberculosis is low or where the environmental burden of saprophytic, nontuberculous mycobacteria is high. Inaccuracy of the tuberculin skin test often reflects a low diagnostic specificity due to the presence in tubercul...

conclusion skin test anergy is uncommon among drug users and the ppd skin test may be reliably used for the identification of latent tb infection in the population. results a total of 221 patients (216 male, mean age 43.5 ± 14.3 years) were studied. tuberculin skin test results showed that 87 subjects (39.4%) tested positive for tb reactivity. reactivity to tetanus and candida antigens were obs...

BACKGROUND Antimicrobial peptides, including cathelicidin LL-37, human beta defensin (HBD)-2, and HBD-3, are important elements of the innate immune response and involved in modulation of the adaptive immunity, and they also play an important role in cutaneous defense against Mycobacterium tuberculosis. METHODS The fresh skin tissues and paraffin-embedded biopsy samples from three cutaneous t...

Skin localizations in disseminated tuberculosis may present a clinical resistant evolution. An 81-year-old woman, treated by long-term steroids and methotrexate for rheumatoid polyarthritis, developed a disseminated tuberculosis in chest, bones and skin. While pulmonary symptoms quickly improved under conventional tuberculostatic drugs, skin ulcers showed positive cultures for 5 months and heal...

background: tuberculosis (tb) remains an important health problem throughout the world. despite its significance in public health, mechanisms of protective immunity against mycobacyerium tuberculosis in humans have not yet been understood. objective: to evaluate cell mediated immune response against purified ag 85, ppd and phytohemagglutinin (pha) in patients with tuberculosis and healthy tuber...

Background: Cutaneous tuberculosis (TB) is a chronic infectious disease affecting the skin caused by Mycobacterium (M. tuberculosis). It constitutes 1–1.5% of extrapulmonary TB, with Indonesia being third-highest TB burden country worldwide. difficult to diagnose due its varied presentations. This study aimed describe clinicodemographic and laboratory characteristics cutaneous in tertiary refer...