This study is focused on in vitro permeation of the original Czech compound, a skin/mucosa tissue regeneration promoter, known under the international nonproprietary name "alaptide," in micronized and nanonized forms. Alaptide showed a great potential for local applications for treatment and/or regeneration of the injured skin. The above mentioned technological modifications influence the perme...

objective(s):the objective of this study was to find a stable microemulsion vehicle for transdermal delivery of ibuprofen to improve the skin permeability. materials and methods: microemulsion was prepared using different sorts of oils, surfactants and co-surfactants. pseudo-ternary phase diagrams were used to evaluate the microemulsion domain. the effects of oleic acid and surfactant mixture o...

Generally, the blood and skin concentration profiles and steady-state skin concentration of topically applied or exposed chemicals can be calculated from the in vitro skin permeation profile. However, these calculation methods are particularly applicable to chemicals for which the main pathway is via the stratum corneum. If the contribution of hair follicles to the total skin permeation of chem...

Several attempts have been made to enhance skin permeation by chemical, physical, or mechanical methods to overcome barrier properties of skin. The present study demonstrates the ability of non-thermal plasma to increase skin permeation and enhance transdermal delivery of large molecules including liposomes (100 nm), nanoparticles (50 nm) & proteins (115 kDa) to deeper layers of the skin rapidl...

Topical fungal infections can become severe if left untreated. Efficient treatment modalities for topical fungal infections aid the penetration of antifungal agents deep into viable skin layers. Terbinafine is a fungicidal agent that inhibits ergosterol, an essential fungal component. The main objective of this study was to evaluate skin permeation and retention of a terbinafine-loaded solution...

Proniosomal formulations with non-ionic surfactant were studied. The effect of hydrophilicity and hydrophobicity of one or two surfactants on drug solubility, proniosome surface structure and stability and skin permeation of haloperidol from different formulations were investigated. Haloperidol (HP) was entrapped in proniosomes with very high efficiency for all formulations. Stability studies p...

BACKGROUND Celecoxib, a selective cyclo-oxygenase-2 inhibitor has been recommended orally for the treatment of arthritis and osteoarthritis. Long term oral administration of celecoxib produces serious gastrointestinal side effects. It is a highly lipophilic, poorly soluble drug with oral bioavailability of around 40% (Capsule). Therefore the aim of the present investigation was to assess the sk...

N,N-Diethyl meta Toluamide (DEET) is an insect repellent agent that contrary to its benefits,if is used in formulations with high skin permeation, will produce side effects of differentseverity. This study attempted to achieve a semi-solid DEET containing formulation withgood appearance, sufficient spreadity, suitable viscosity for tube and jar filling, compatible pHwith skin, reasonable stabil...

A reservoir type transdermal patch for delivery of ketorolac, a potent analgesic agent was studied. The low permeability of skin is the rate-limiting step for delivery of most of the drugs. Studies were carried out to investigate the effect of permeation enhancers on the in vitro permeation of ketorolac across rat skin. The reservoir type transdermal patch was fabricated and the core was filled...

The objective of our present work was to prepare transdermal matrix patches containing the drug, diclofenac diethylamine with various polymeric combinations of polyvinylpyrrolidone and ethylcellulose and to study the mechanism of release of the drug from the patches and its skin permeation. Sorbitan monolaurate 20 (Span 20), a non-ionic surfactant was added to the concentrations (0.1% wt/vol), ...