Delivering medicine to the general circulation through the skin is associated with grater advantages compared to that by the oral route and hence the purpose of this investigation was to study the potential of rosiglitazone maleate for transdermal delivery using passive diffusion and iontophoresis. Physicochemical parameters of rosiglitazone maleate like solubility, pKa, octanol/vehicle and ski...

OBJECTIVE Psoriasis is a chronic inflammatory skin disease and topical therapy remains a key role for treatment. The aim of this study is to evaluate the influence of psoriasis-like lesions on the cutaneous permeation of anti-psoriatic drugs. METHODS We first set up imiquimod-induced dermatitis in mice that closely resembles human psoriasis lesions. The development of the lesions is based on ...

Neat N-methyl-2-pyrrolidone (NMP) rapidly penetrated into the skin of male Sprague-Dawley rats after in vivo and in vitro topical application. At the two topical doses tested in vivo, no steady state was observed. The maximal absorption fluxes were 10 and 20 mg/cm(2)/h for 20 microl/cm(2) and 40 microl/cm(2), respectively. Similar results were observed after in vitro topical application of neat...

the aim of the present study was to develop and investigate the feasibility of delivering nebivolol as a transdermal patch by iontophoresis. the passive and electrically assisted transdermal delivery of nebivolol hydrochloride by iontophoresis will improve the therapeutic efficacy and overcome the difficulties raised in oral drug delivery. because of its extensive hepatic metabolism and low dos...

The aim of the present study was to develop and investigate the feasibility of delivering Nebivolol as a transdermal patch by iontophoresis. The passive and electrically assisted transdermal delivery of Nebivolol hydrochloride by iontophoresis will improve the therapeutic efficacy and overcome the difficulties raised in oral drug delivery. Because of its extensive hepatic metabolism and low dos...

The UMTRI Airbag Skin Burn Model has been improved through laboratory testing and the implementation of a more flexible heat transfer model. A new impinging jet module based on laboratory measurements of heat flux due to high-velocity gas jets has been added, along with an implicit finite-difference skin conduction module. The new model can be used with airbag gas dynamics simulation outputs, o...

INTRODUCTION The treatment of scleroderma-related digital ulcers is challenging. The oral endothelin receptor antagonist (ERA) bosentan has been approved but it may induce liver toxicity. The objective of this study was to test whether ERAs bosentan and sitaxentan could be locally delivered using iontophoresis. METHODS Cathodal and anodal iontophoresis of bosentan and sitaxentan were performe...

The amphibian skin has long been used as a model tissue for the study of ion transport and osmotic water movement across tight epithelia. To understand the mechanism of water uptake across amphibian skin, we model the skin as a well-stirred compartment bounded by an apical barrier and a tissue barrier. The compartment represents the lateral intercellular space between cells in the stratum granu...

The objective of this work is to evaluate the effect of polyamidoamine (PAMAM) dendrimers on electroosmotic flow (EOF) through skin. The effect of size and concentration of dendrimer was studied, using generation 1, 4 and 7 dendrimer (G1, G4 and G7, respectively). As a marker molecule for the direction and magnitude of EOF, a neutral molecule, acetoaminophen (AAP) was used. The visualization of...

Transdermal delivery of topically applied compounds is limited by the stratum corneum (SC) protective barrier. Penetration enhancers have been employed to perturb the skin barrier and enhance the transdermal flux of drugs. The novel excipient, dodecyl-2-N, N-dimethylaminopropionate hydrochloride (DDAIP-HCl), was evaluated for penetration activity of minoxidil in human cadaver skin. Minoxidil sk...