PURPOSE This is a meta-analysis of randomized, controlled trials to assess the efficacy and morbidity of medical therapies for anal fissure. METHODS Medline and the Cochrane Controlled Trials Register and the Cochrane Colorectal Cancer Review Groups Controlled Trials Register were searched using the terms "anal fissure randomized" from 1966 to 2002. Studies in which participants were randomiz...

The optic fissure is a transient gap in the developing vertebrate eye, which must be closed as development proceeds. A persisting optic fissure, coloboma, is a major cause for blindness in children. Multiple factors are genetically linked to coloboma formation. However, especially the process of optic fissure fusion is still largely elusive on a cellular and molecular basis. We found a coloboma...

BACKGROUND Bronchoscopic thermal vapor ablation (BTVA) ablates emphysematous tissue through a localized inflammatory response followed by contractive fibrosis and tissue shrinkage leading to lung volume reduction that should not be influenced by collateral ventilation. OBJECTIVES To determine the correlation of clinical data from a trial of BTVA with fissure integrity visually assessed by com...

BACKGROUND Multi-detector Computed Tomography has become an invaluable tool for the diagnosis of chronic respiratory diseases. Based on CT images, the automatic algorithm to detect the fissures and divide the lung into five lobes will help regionally quantify, amongst others, the lung density, texture, airway and, blood vessel structures, ventilation and perfusion. METHODS Sagittal adaptive f...

The gene networks underlying closure of the optic fissure during vertebrate eye development are poorly understood. Here, we profile global gene expression during optic fissure closure using laser capture microdissected (LCM) tissue from the margins of the fissure. From these data, we identify a unique role for the C(2)H(2) zinc finger proteins Nlz1 and Nlz2 in normal fissure closure. Gene knock...

the aim of this study was to investigate the mechanical properties (flexural strength, micro-shear bond strength) and remineralizing potential of fissure sealants by adding various concentrations of β-tricalcium phosphate nanoparticles.this in-vitro study consisted of five experimental groups containing prepared nano-fisssure sealants (1-5 wt.% β-tcp nanoparticles) and two control groups contai...

The Knowledge of variations in the lung can help surgeons to control bleeding during pulmonary lobectomy or might be used to reduce post-operative complications. Due to the importance of the knowledge of variations in lungs for clinicians, especially surgeons and radiologists, we report a case with lung lobe and fissure. During the autopsy of a 27-year-old man at the Legal Medicine Organizatio...

The azygos fissure is typically visible on chest radiography as a right paramediastinal supernumerary line in projection of the right lung apex. The azygos vein, located at the bottom of the fissure, is visible as a teardrop-shaped opacity. The empty azygos fissure is a rare finding. It is the consequence of the displacement of the azygos vein out of the fissure with a close paramediastinal pos...

Coloboma is a defect in the morphogenesis of the eye that is a consequence of failure of choroid fissure fusion. It is among the most common congenital defects in humans and can significantly impact vision. However, very little is known about the cellular mechanisms that regulate choroid fissure closure. Using high-resolution confocal imaging of the zebrafish optic cup, we find that apico-basal...