background : burn wounds are one of the health problems in modern societies that are associated with irreparable harms and many side problems for patients and their families. infection due to burn wounds is the main cause of death in such patients. one of the methods to prevent infection of burn wounds is topical antibiotic ointments. this study aimed to investigate and identify effective ointm...

The skin is a tissue which is the most exposed to external factors. It is formed by numerous specialized cells and performs mainly protective functions. Due to its special properties such as: resistance, elasticity and semipermeability, it protects our body from mechanical injuries, infections, loss of physiological fluids as well as harmful radiation (1, 2). The human skin is formed of multi-l...

BACKGROUND Full-thickness burn wounds require excision and skin grafting. Multiple surgical procedures are inevitable in managing moderate to severe full-thickness burns. Wound bed preparations prior to surgery are necessary in order to prevent wound infection and promote wound healing. Honey can be used to treat burn wounds. However, not all the honey is the same. This study aims to evaluate t...

OBJECTIVES The pathogenesis of burn wound progression is poorly understood. Contributing factors include continuous loss of blood perfusion, excessive inflammation, and elevated apoptosis levels in wound tissue. Macroautophagy (here referred to simply as "autophagy") is associated with many chronic diseases. The authors hypothesized that autophagy is involved in burn wound progression in a rat ...

After first success of epidermal autotransplantation onto a granulating wound in 1869, skin graft become a standard option for closing defect that cannot be closed primarily. [1] Skin graft can be used in various clinical situations. For the reconstruction of traumatic wounds, burn wound, soft tissue defect or skin defect after cancer ablation surgery or after removal of pigmented skin lesion, ...

ABSTRACT               Background and Objectives: Current medications used for the treatment of burn wounds have some side effects and disadvantages. Oral or topical administration of probiotic bacteria is thought to be useful for treatment of skin disorders. The aim of this study was to evaluate effects of spray-dried Streptococcus thermophilus on healing of second-degree burn wounds.       ...

Healing of burn wounds is often associated with scar formation due to excessive inflammation and delayed wound closure. To date, no effective treatment is available to prevent the fibrotic process. The Renin Angiotensin System (RAS) was shown to be involved in fibrosis in various organs. Statins (e.g. Atorvastatin), Angiotensin receptor antagonists (e.g. Losartan) and the combination of these d...

Thermal injuries may cause significant damage to large areas of the skin. Extensive and deep burn wounds require specialistic therapy. The optimal method in the strategy of treating extensive, full thickness burns (III°) is the use of autologous free skin grafts of intermediate thickness (1-4). The main limitation of this method is the inadequate amount of healthy, undamaged skin (donor site), ...

OBJECTIVE Certain cytokines, especially those known as growth factors, have been demonstrated to mediate or modulate burn wound healing. Experimental and clinical evidence suggests that there are therapeutic advantages to the wound healing process when these agents are utilized. Positive effects have been reported for 4 types of wounds seen in the burn patient: partial-thickness wounds, full-th...

Introduction: Re-epithelialisation of cutaneous wounds is a complex multistep process. In partial thickness wounds, keratinocytes from wound edges and the remnants of the epidermal appendages contribute to the process. We investigated whether the mechanism of injury had any influence on reepithelialisation of partial thickness wounds in a porcine model. Method: Partial thickness wounds were cre...