The N-CoR/SMRT complex containing mSin3 and histone deacetylase (HDAC) mediates transcriptional repression by nuclear hormone receptors and Mad. The proteins encoded by the ski proto-oncogene family directly bind to N-CoR/SMRT and mSin3A, and forms a complex with HDAC. c-Ski and its related gene product Sno are required for transcriptional repression by Mad and thyroid hormone receptor (TRbeta)...

Govus, A., Marsland, F., Martin, D., & Chapman, D. (2015). Validity and reliability of an incremental double poling protocol in cross-country skiers. J. Hum. Sport Exerc., 10(3), pp.827-834. This study determined the validity and reliability of an incremental double poling protocol performed on a Concept II ski-ergometer and validated this against an existing treadmill ski-striding protocol. Te...

Overexpression of the oncoprotein SKI correlates with the progression of human melanoma in vivo. SKI is known to curtail the growth inhibitory activity of tumor growth factor through the formation of repressive transcriptional complexes with Smad2 and Smad3 at the p21 promoter. Here, we show that SKI also stimulates growth by activating the Wnt signaling pathway. From a yeast two-hybrid screen ...

The ski/sno protooncogenes encode nuclear proteins that may act as transcription factors. We examined ski and sno mRNA expression in hemolymphopoietic lineages. The ski protooncogene is expressed in B- and T-lineage cells, mature macrophages, and mast cells. In normal murine marrow-derived progenitors analyzed by single-cell reverse transcription-polymerase chain reaction (RT-PCR), ski expressi...

Epithelial-mesenchymal transition (EMT) is a key event in cancer metastasis, which confers cancer cells with increased motility and invasiveness, and EMT is characterized by loss of epithelial marker E-cadherin and gain of mesenchymal marker N-cadherin. Transforming growth factor-β (TGF-β) signaling is a crucial inducer of EMT in various types of cancer. Ski is an important negative regulator o...

Using a unique database of 85 ski resorts and 1,524 lifts and cable cars in Austria, we investigate the relationship between lift ticket prices for the 2005-2006 season and factors that influence the quality of ski resorts. We estimate a hedonic price function using OLS and robust regression techniques on length of ski runs, transport capacity (measured as vertical transport metres per hour), s...

Ski, the transforming protein of the avian Sloan-Kettering retrovirus, inhibits transforming growth factor-β (TGF-β)/Smad signaling and displays both pro-oncogenic and anti-oncogenic activities in human cancer. Inhibition of TGF-β signaling is likely responsible for the pro-oncogenic activity of Ski. We investigated the mechanism(s) underlying the tumor suppressor activity of Ski and found that...

Transcription factor Glioblastoma-3 (Gli3) is cleaved in the anterior region of the limb bud to generate its repressor form. In contrast, Sonic hedgehog (Shh) signaling from the posterior zone of polarizing activity blocks Gli3 processing and then induces the expression of Gli3 target genes, including Gli1. Here we report that the Ski corepressor binds to Gli3 and recruits the histone deacetyla...

The Ski family of nuclear oncoproteins represses TGF-beta signaling through interactions with the Smad proteins. The crystal structure of the Smad4 binding domain of human c-Ski in complex with the MH2 domain of Smad4 reveals specific recognition of the Smad4 L3 loop region by a highly conserved interaction loop (I loop) from Ski. The Ski binding surface on Smad4 significantly overlaps with tha...

The purpose of the study was to examine potential differences between male and female alpine ski naive young people in attitudes towards alpine skiing before and after the completion of structured alpine ski school program. We included 136 ski beginners (41 women and 95 men) who anonymously filled out a previously validated 26-item Lickert scale-type questionnaire related to their attitudes tow...