Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by production of numerous antibodies that may affect multiple organ systems. Wide variety of systemic features of SLE are attributed to antibodies against the components of cell nuclei. Many of the clinical features, like nephritis and arthritis are due to deposition of immune complexes resulting in tissue damage. Other f...

Background Sjogrens syndrome (SS) is a chronic autoimmune disorder, characterised by lymphocytic infiltration resulting in exocrine gland destruction and other extra-glandular manifestations [1]. Currently there is no definitive diagnostic test, and the immuno-pathology is not fully understood. Recently focus has shifted to investigating microRNAs (miRs) in an effort to understand the mechanism...

Background: Idiopathic longitudinally extensive transverse myelitis is defined as a focal spinal cord lesion that involves three or more segments of the shown by neuroimaging, and results in profound disability. The clinical picture patient with idiopathic advanced often dramatic may consist paraparesis tetraparesis, sensory disturbances, pelvic dysfunction. common manifestation neuromyelitis o...

OBJECTIVE Microparticles (MPs) are membrane-bound vesicles derived from vascular and intravascular cells such as endothelial cells (EMPs) and platelets (PMPs). We investigated EMP and PMP numbers across a spectrum of autoimmune rheumatic diseases (AIRDs) with the aim of comparing the levels of, and relationship between, EMPs and PMPs. METHODS Patients with Systemic Lupus Erythematosus (SLE) (...

Congenital Heart Block (CHB) is the most serious complication of neonatal lupus erythematosus. Transplasental transfer of maternal anti SSA/Ro or antiSSB/La antibodies around 12th week of gestation is associated with development of CHB. This may lead to inflammation, fibrosis and scarring of fetal conduction system in the early second trimester. Different degrees of atrioventricular (AV) block ...

A common classification of cerebral vasculitis uses the size of the affected arteries and the etiology of the wall inflammation, but this classification scheme was established for systemic disease rather than cerebral disease [1,2,3,4]. Another way to classify cerebral vasculitis has been proposed by Kuker [4] dividing it into large vessel vasculitis (LVV), medium vessel vasculitis (MVV), and s...