Diseases characterized by proliferative changes in the reticulo-endothelial system, other than the leukaemias and specific infections such as tuberculosis and typhoid fever, give rise to three main syndromes in children, but there are many atypical and intermediate forms. Originally described as three separate conditions, these syndromes, namely Letterer-Siwe disease, Hand-Schiiller-Christian s...

The fourteenth annual meeting of the Society for Pediatric Dennatology was held in Quebec City, Quebec, Canada and hosted by Drs. Beraice Krafchik, Lionel Boxall, and the dennatology staff of L'Hotel-Dieu de Quebec, particularly Drs. Raymond Lessard and Richard Cloutier. The fifth annual Sidney Hurwitz Lecture was presented by Professor Ruggero Caputo of the University of Milan. He discussed th...

histiocytosis of langerhans cells (class 1 histiocytosis) consists of a range of clinical manifestations, including bone eosinophilic granuloma, hand-schüller-christian syndrome, and letterer-siwe disease. these syndromes represent a spectrum of severity and prognosis of an underlying disorder which is usually sporadic. this report describes three cases in one family, who developed the disease ...

Langerhans cell histiocytosis includes a broad spectrum of clinical diseases resulted from proliferation and tissue infiltration of differentiated langerhans cells. This term includes Letterer-siwe disease, Hand-Schuller-Christian disease, eosinophilic granuloma and congenital reticulohistiocytosis that are more common in children than adults. This entity has recently been classified into restr...

Langerhans cell histiocytosis (LCH), mainly affects the skull, vertebrae, ribs and mandible in children and the long bones of adults. Symptoms range from none to pain, swelling and tenderness over the site of the lesion. This disease presents oral manifestations which can sometimes be the first expression of the condition. It occurs in three forms namely eosinophilic granuloma in which isolated...

Langerhans cell histiocytosis (LCH) is a heterogeneous group of diseases characterized by a pathological proliferation of cells phenotypically similar to Langerhans cells. The disease course is variable, alternating between resolving and potentially fatal forms. The diagnosis is based on clinical appearance and confirmed by CD1a positivity and / or immunohistochemistry. We report the case of a ...