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تعداد نتایج: 1325127 فیلتر نتایج به سال:
با توجه به حیاتی بودن نقش آنزیم topo ii در چرخه سلولی، این آنزیم میتواند هدف درمانی مهمی در شیمی درمانی سرطان باشد. فلوروکینولون ها به عنوان مهارکننده های آنزیم توپوایزومراز (ژیراز) باکتری به خوبی شناخته شده اند و اخیرا نیز نشان داده شده است که توان مهار توپوایزومراز ii یوکاریوتیکها را هم دارند. در این راستا در این پایان نامه ترکیبات جدیدی از فلوروکینولونها به منظور مهار آنزیم توپوایزومراز انسا...
We develop an analytical model of a separating equilibrium for a two-tier fee-based and sponsored-based information Web site. We examine the monopolist’s choice of content quality and price for a feebased site targeted at high type consumers and the content quality level for a sponsored site offered free to all consumers. We show how a reduction in the potential for advertising revenues results...
Respondents at an Internet site completed over 600,000 tasks between October 1998 and April 2000 measuring attitudes toward and stereotypes of social groups. Their responses demonstrated, on average, implicit preference for White over Black and young over old and stereotypic associations linking male terms with science and career and female terms with liberal arts and family. The main purpose w...
This study identifies two distinct conceptualizations of interactivity in the communication literature—the functional view and the contingency view. Although the functional view has predominated academic research on interactivity, this study operationalizes the contingency view in the context of an experiment designed to investigate the impression formation effects of interactivity in Web-based...
CONTEXT Individuals searching the Internet for vaccine information may find antivaccination Web sites. Few published studies have systematically evaluated these sites. OBJECTIVES To examine antivaccination Web site attributes and to delineate the specific claims and concerns expressed by antivaccination groups. DESIGN AND SETTING In late 2000, using a metasearch program that incorporates 10...
The movement protein genes from several isolates of ArMV and GFLV of different geographical origins were amplified by RT/PCR using degenerate primers, cloned and sequenced. A single pair of degenerate primers was designed from these sequences to allow the simultaneous amplification of parts of the movement protein genes of ArMV and GFLV. Their use in an immunocapture-RT/PCR for the detection of...
Stereoscopic observation by the CANGAROO-III imaging Cherenkov telescopes will be performed by operating four telescopes simultaneously with various operation modes. High quality control system of such multi-telescopes to achieve various types of observation demands has been constructed and tested. pp. 2867–2870 c ©2003 by Universal Academy Press, Inc.
The covarion (COV)-like properties of sequences are poorly described and their impact on phylogenetic analyses poorly understood. We demonstrate using simulations that, under an evolutionary model where the proportion of variable sites changes in nonadjacent lineages, log likelihood values for rates across site (RAS) and COV models become similar, making models difficult to distinguish. Further...
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