background: breast cancer is the first leading cause of cancer-related death in women. pesticides which are excessively used in northern iran are one of the most important risk factors for breast cancer incidence. the cytochrome p450 1a1 (cyp1a1) is a key enzyme in xenobiotics metabolism and snps of its coding gene has been verified to be important in cancer susceptibility. the aim of this stud...

introduction: using addictive drugs can change the amount of neurotransmitters, especially dopamine and glutamate. glutamate has been known to trigger the relapse and tendency toward addictive drugs. the glutamate receptor ionotropic nmda type subunit 1 (grin1) contains the single- nucleotide polymorphism c1001g (rs11146020) and encodes n-methyl-d-aspartic acid (ndma) receptor subunit 1 (nr1). ...

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background three single nucleotide polymorphisms (snps) near interleukin-28b (il-28b) gene were shown to be highly associated with treatment response (svr) in patients with chronic hepatitis c virus (hcv) infection. there is limited data about the role of single and combined il-28b polymorphisms in hcv-infected polish population. objectives this study's aim was to determine predictability of th...

conclusions our results showed for the first time that lyplal1 gene is not associated with a risk of nafld development in the chinese han population. the variant carriers of overall subjects significantly increased weight, bmi and ldl. patients and methods lyplal1 rs12137855 gene was genotyped in 184 patients with nafld and 114 healthy controls using sequencing and polymerase chain reaction ana...

conclusions trim22 gene ring domain -364t/c polymorphism is associated with chronic hbv infection in chinese han population. results 243 (31.76%) of 765 chinese han patients showed genetic variation in the trim22 gene. trim22 snps were mainly in ring area -364t/c site, accounting for 98.35% of the population. there were no significant differences (p > 0.05) in the ring domain -364t/c snp and al...

matrix metalloproteinases (mmps) play an important role in gastric cancer (gc). accumulated evidence suggests that functional mmp-1 and mmp-7 gene polymorphisms are associated with several tumors. the aim of this study was to investigate two single nucleotide polymorphisms, mmp-1 -1607 1g/2g and mmp-7 -181 a/g, and their potential relationship with gc. we examined 246 gc  patients and 252 age-a...

objective(s): to investigate the association of single nucleotide polymorphisms (snps) in the peroxisome proliferator-activated receptors gamma (pparg) with essential hypertension (eh) and additional role of gene– high-density lipoprotein cholesterol (hdl) interaction. materials and methods:a total of 1640 patients with eh (806 males, 834 females), with a mean age of 52.5±12.6 years, were selec...

molecular genetics selection on individual genes is a promising method to genetically improve economically important traits in livestock. the insulin like growth factor-i (igf-i) gene may play important roles in growth of multiple tissues, including muscle cells, cartilage and bone. the objectives of the present study were the estimate the haplotype frequencies of the igf-i gene polymorphisms i...