نتایج جستجو برای: simvastatin

تعداد نتایج: 13002  

بنی کریم, اردشیر, خوری, وحید, علیزاده, علی محمد, علیزاده, فاطمه,

Background: The 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhi-bitors (statins) have revolutionized the treatment of hypercholesterolemia. Some evide-nce indicated the role of nodal refractoriness and concealed conduction in anticipating the ventricular rate during atrial fibrillation. Recent evidence has indicated that statins can reduce the incidence of both supraventricular a...

Journal: :iranian journal of pharmaceutical sciences 0
mohammad javad khoshnoud department of toxicology and pharmacology, faculty of pharmacy baligh naji abdeh moghbel department of toxicology and pharmacology, faculty of pharmacy bita geramizadeh department of pathology, faculty of medicine hossein niknahad department of toxicology and pharmacology, faculty of pharmacy; pharmaceutical sciences research center, shiraz university of medical sciences, shiraz, iran

statins have antioxidant and anti-inflammatory effects that are not directly related to their cholesterol-lowering activity. this study aimed to investigate the effect of simvastatin on the extent of tissue damage in cisplatin-induced nephrotoxicity. simvastatin was orally given to rats in different doses (1, 2 and 4 mg/kg), 1 h prior to cisplatin injection (5 mg/kg, i.p.). all animals were dec...

Objective(s): Chemokines are wound mediators that promote angiogenesis during wound healing. We hypothesized that Simvastatin in combination with the bone marrow mesenchymal stromal cells (BMSCs) improve burn wound healing by ameliorating angiogenesis via SDF-1α/CXCR4 pathway.Materials and Methods: Under general anesthesia, deep partial-...

2014
XIN HUANG ZHONGMING HUANG WEIXU LI

A number of clinical and experimental studies have investigated the effect of simvastatin on bone regeneration. In the present study, the release of simvastatin from simvastatin-loaded calcium sulphate (CS) scaffolds and the effect of these scaffolds on osteogenic differentiation of bone marrow-derived mesenchymal stem cells (MSCs) in vitro and the effect of simvastatin locally applied from CS ...

Abbas Mohammadi Behnaz Danesh Hossein Fallah, Mostafa Allahyari,

Backgrounds: Type 2 diabetes mellitus is the most common metabolic disease and free fatty acids, as signaling molecules, can play a crucial role in the development of it. Different free fatty acids, through various cell membrane receptors, induce different effects on metabolic pathways and thereby affect insulin sensitivity. Simvastatin is a cholesterol decreasing drug prescrib...

2009
Jieli Chen Xu Cui Alex Zacharek Michael Chopp

In this study, we tested the hypothesis that the Angiopoietin 1 (Ang1)/Tie2 pathway mediates simvastatin-induced vascular integrity and migration of neuroblasts after stroke. Rats were subjected to 2 hrs of middle cerebral artery occlusion (MCAo) and treated, starting 1 day after stroke with or without simvastatin (1 mg/kg, daily) for 7 days. Simvastatin treatment significantly decreased blood-...

Journal: :Neurosciences 2012
Fatma S Kilic Yasemin Ozatik Bilgin Kaygisiz Canan Baydemir Kevser Erol

OBJECTIVE The aim of this study is to investigate the antidepressant and anxiolytic effects of simvastatin in rats. METHODS Sixty-four male adult (8-9 weeks old) Sprague-Dawley rats (200-250 g) were used. The forced swimming test and the elevated plus maze test were used for testing the antidepressant and anxiolytic effects. Eight groups were formed: control (saline), simvastatin 10, 30, and ...

Behnaz Danesh Gholam Abbas Mohammadi Hosein Fallah, Samaneh Rahemi

Backgrounds: Insulin resistance is a pathological condition associated with metabolic syndrome. In this condition, insulin action in liver, muscles, and adipocytes decreases which leads to hyperglycemia, hyperinsulinemia, and dyslipidemia. Thiazolidinediones (Pioglitazone) have been used to enhance insulin sensitivity but due to dyslipidemia associated with insulin resistance, ...

ژورنال: ارمغان دانش 2020

Background & aim: Cancer is a disharmony amongst cell growth and death which results in accumulation of cells. Bone cancer is an absolutely dangerous type of cancer and occurs when the bone-making cells are disrupted. Despite some reports on the anticancer effects of simvastatin, the activity of simvastatin on bone cancer cells has not been reported. The aim of this study was to evaluate the cy...

Journal: :iranian red crescent medical journal 0
elham pourmatroud obstetrics and gynecology department, infertility fellow, emam khomeini hospital, ahvaz jundishapur university of medical sciences, ahvaz, ir iran; obstetrics and gynecology department, infertility fellow, emam khomeini hospital, ahvaz jundishapur university of medical sciences, ahvaz, ir iran. tel: +98-9123888405, fax: +98-6114466512 razieh mohammadjafari obstetrics and gynecology department, ahvaz jundishapur university of medical sciences, ahvaz, ir iran mandana roozitalab obstetrics and gynecology department, ahvaz jundishapur university of medical sciences, ahvaz, ir iran

conclusions simvastatin effectively improved hyperandrogenism signs and symptoms in patients with pco, but this effect as a pretreatment regiment was not more expressive than metformin in icsi cycle outcome. patients and methods in this prospective, double blind, randomized clinical trial the efficacy of these drugs was evaluated in 40 women with pco syndrome (20 patients in each group; a: simv...

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