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Sigma-1 receptors (Sig-1Rs) have been implicated in many neurological and psychiatric conditions. Sig-1Rs are intracellular chaperones that reside specifically at the endoplasmic reticulum (ER)-mitochondrion interface, referred to as the mitochondrion-associated ER membrane (MAM). Here, Sig-1Rs regulate ER-mitochondrion Ca(2+) signaling. In this review, we discuss the current understanding of S...
Sigma-1 receptor (Sig-1R) functions as a chaperon that interacts with multiple proteins and lipids and is implicated in neurodegenerative and psychiatric diseases. Here, we used Sig-1R KO mice to examine brain expression profiles of astrocytes and ubiquitinated proteins, which are both hallmarks of central nervous system (CNS) pathologies. Our results showed that Sig-1R KO induces increased gli...
One theory concerning the action of antidepressants relates to the drugs' ability to induce an adaptive plasticity in neurons such as neurite sprouting. Certain antidepressants are known to bind to sigma-1 receptors (Sig-1R) with high affinity. Sig-1R are dynamic endoplasmic reticulum proteins that are highly concentrated at the tip of growth cones in cultured cells. We therefore tested the hyp...
this article presents a unified approach to the abstract notions of partial convolution and involution in $l^p$-function spaces over semi-direct product of locally compact groups. let $h$ and $k$ be locally compact groups and $tau:hto aut(k)$ be a continuous homomorphism. let $g_tau=hltimes_tau k$ be the semi-direct product of $h$ and $k$ with respect to $tau$. we define left and right $tau$-c...
This report records and discusses the Fourth Workshop on Sustainable Software for Science: Practice and Experiences (WSSSPE4). The report includes a description of the keynote presentation of the workshop, the mission and vision statements that were drafted at the workshop and finalized shortly after it, a set of idea papers, position papers, experience papers, demos, and lightning talks, and a...
چکیده: پژوهش حاضر در پی بررسی تاثیر استفاده از شبکه های ماهواره ای bbc فارسی و farsi1 برافکار و عقاید جوانان شهرستان روانسر می باشد. روش مورد استفاده در این تحقیق روش پیمایشی می باشد و تکنیک و ابزار گردآوری اطلاعات، پرسشنامه محقق ساخته و مصاحبه پیش آزمون می باشد. جامعه آماری این تحقیق، جوانان شهرستان روانسر می باشند. که از طریق فرمول کوکران حجم نمونه 200 نفر برآورد شده است و برای دسترسی به ن...
Living organisms are constrained by both resource quantity and quality. Ecological stoichiometry offers important insights into how the elemental composition of resources affects their consumers. If resource quality decreases, consumers can respond by shifting their body stoichiometry, avoiding low-quality resources, or up-regulating feeding rates to maintain the supply of required elements whi...
Many fascinating new developments in the area bowed stringed instruments have been developed in recent years. However, the majority of these new applications are either not well known, used or considered in a broader context by their target users. The necessary exchange between the world of developers and the players is rather limited. A group of performers, researchers, instrument developers a...
Sigma-1 receptors (Sig-1Rs) that bind diverse synthetic and endogenous compounds have been implicated in the pathophysiology of several human diseases such as drug addiction, depression, neurodegenerative disorders, pain-related disorders, and cancer. Sig-1Rs were identified recently as novel ligand-operated molecular chaperones. Although Sig-1Rs are predominantly expressed at endoplasmic retic...
Copyright c © 0000 John Wiley & Sons, Ltd. Softw. Pract. Exper. (0000) Prepared using speauth.cls DOI: 10.1002/spe
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