نتایج جستجو برای: shbg
تعداد نتایج: 1178 فیلتر نتایج به سال:
Epidemiological studies consistently show that circulating sex hormone binding globulin (SHBG) levels are lower in type 2 diabetes patients than non-diabetic individuals, but the causal nature of this association is controversial. Genetic studies can help dissect causal directions of epidemiological associations because genotypes are much less likely to be confounded, biased or influenced by di...
OBJECTIVE Experimental evidence suggests that fetal exposure to androgen excess may program the development of polycystic ovary syndrome (PCOS) in utero. The aim of this study was to examine whether the sex hormone binding globulin (SHBG)(TAAAA)n and the cytochrome P450, family 19 (CYP19)(TTTA)n polymorphisms, known to influence sex hormone-binding globulin (SHBG) levels and aromatase activity ...
Stimulation of the androgen receptor via bioavailable androgens, including testosterone and testosterone metabolites, is a key driver of prostate development and the early stages of prostate cancer. Androgens are hydrophobic and as such require carrier proteins, including sex hormone-binding globulin (SHBG), to enable efficient distribution from sites of biosynthesis to target tissues. The simi...
این پژوهش از نوع نیمه تجربی با طرح پیش آزمون ـ پس آزمون بود. 24 نفر از زنان دیابتی شهر یزد با دامنه سنی 76/0±92/47 سال، وزن 56/3±03/74 (کیلوگرم )، قد 48/0±33/157 (سانتی متر) و شاخص توده بدن (bmi) 37/1±09/30 (کیلوگرم بر متر مربع)، به طور داوطلبانه انتخاب شدند. آزمودنی ها به طور تصادفی به دو گروه تمرینات پیلاتس (گروه یک12=n) و گروه کنترل (گروه دو12=n) تقسیم شدند. قد، وزن، درصد چربی، bmi، whr، fbs...
La proteïna transportadora de les hormones sexuals (SHBG) va ser descrita a finals dels anys seixanta amb les funcions de transportar els esteroides sexuals i de regular-ne la biodisponibilitat. Des de fa ja bastant temps, es coneix també que les cèll . ules testiculars de Sertoli expressen la proteïna que lliga els andrògens (androgen-binding protein oABP), que està codificada pel mateix gen q...
The serum concentration of sex hormone-binding globulin (SHBG) is inversely related to weight and in animal studies is inversely related to protein intake. As SHBG can affect the biological activity of testosterone and estradiol, we wished to determine the role of protein intake on SHBG levels in men. Using data from the Massachusetts Male Aging Study we examined cross-sectional relationships b...
Gonadal steroids are known to influence hypothalamic functions through both genomic and non-genomic pathways. Sex hormone-binding globulin (SHBG) may act by a non-genomic mechanism independent of classical steroid receptors. Here we describe the immunocytochemical mapping of SHBG-containing neurons and nerve fibers in the human hypothalamus and infundibulum. Mass spectrometry and Western blot a...
PURPOSE Sex hormone-binding globulin (SHBG) modulates the availability of biologically active free sex hormones. The regulatory role of SHBG might be important in the relationship between hormone levels and the modification of lipid profiles in girls with precocious puberty. However, few studies have evaluated the relationship of SHBG, free estradiol index (FEI), and lipid levels in these girls...
A genomic cosmid clone for human sex hormone binding globulin (SHBG), a liver-secreted plasma glycoprotein that binds sex steroids, was isolated with a previously characterized liver cDNA as probe. Southern blot analysis of genomic DNA indicated that only one SHBG gene is present in the human haploid genome. A 3.8 Kb Xba I-fragment of the clone containing the entire coding region of SHBG was se...
Human sex hormone-binding globulin (SHBG) transports sex steroids in the blood. It functions as a homodimer, but there is little information about the topography of its dimerization domain, and its steroid binding stoichiometry is controversial. The prevailing assumption is that each homodimeric SHBG molecule contains a single steroid-binding site at the dimer interface. However, crystallograph...
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